PDE6H Antibody (G-2): sc-398478
- PDE6H Antibody (G-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 14-83 representing full length PDE6H of human origin
- PDE6H Antibody (G-2) is recommended for detection of PDE6H of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-PDE6H Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDE6H Antibody (G-2). This work is in progress.
PDE6H Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDE6H in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PDE6H antibody (G-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PDE6H plays a critical role in the phototransduction pathway, specifically in the retina, where PDE6H is involved in the conversion of light signals into electrical signals, a process essential for vision. Mutations or dysregulation of PDE6H can lead to retinal diseases, highlighting PDE6H′s importance in maintaining visual function. PDE6H is localized in the photoreceptor cells of the retina, where PDE6H interacts with other proteins such as phosphodiesterase 6 (PDE6) and guanylate cyclase, which are vital for the proper functioning of phototransduction. Understanding the interactions and functions of PDE6H is crucial for developing therapeutic strategies for retinal disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PDE6H Antibody (G-2) References:
- The genomic context of natural killer receptor extended gene families. | Trowsdale, J., et al. 2001. Immunol Rev. 181: 20-38. PMID: 11513141
- Genotype/phenotype analysis in a patient with pure and complete trisomy 12p. | Zumkeller, W., et al. 2004. Am J Med Genet A. 129A: 261-4. PMID: 15326625
- The phenotypic spectrum of COL2A1 mutations. | Nishimura, G., et al. 2005. Hum Mutat. 26: 36-43. PMID: 15895462
- Comparative genomics of natural killer cell receptor gene clusters. | Kelley, J., et al. 2005. PLoS Genet. 1: 129-39. PMID: 16132082
- The natural history of trisomy 12p. | Segel, R., et al. 2006. Am J Med Genet A. 140: 695-703. PMID: 16502429
- Noonan syndrome. | van der Burgt, I. 2007. Orphanet J Rare Dis. 2: 4. PMID: 17222357
- Cytogenetic and molecular analysis in trisomy 12p. | Allen, TL., et al. 1996. Am J Med Genet. 63: 250-6. PMID: 8723118
- Low basal transcripts of the COL2A1 collagen gene from lymphoblasts show alternative splicing of exon 12 in the Kniest form of spondyloepiphyseal dysplasia. | Yang, W. and Cole, WG. 1998. Hum Mutat. Suppl 1: S1-2. PMID: 9452022
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDE6H Antibody (G-2) | sc-398478 | 200 µg/ml | $316.00 | |||
PDE6H Antibody (G-2) AC | sc-398478 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PDE6H Antibody (G-2) HRP | sc-398478 HRP | 200 µg/ml | $316.00 | |||
PDE6H Antibody (G-2) FITC | sc-398478 FITC | 200 µg/ml | $330.00 | |||
PDE6H Antibody (G-2) PE | sc-398478 PE | 200 µg/ml | $343.00 | |||
PDE6H Antibody (G-2) Alexa Fluor® 488 | sc-398478 AF488 | 200 µg/ml | $357.00 | |||
PDE6H Antibody (G-2) Alexa Fluor® 546 | sc-398478 AF546 | 200 µg/ml | $357.00 | |||
PDE6H Antibody (G-2) Alexa Fluor® 594 | sc-398478 AF594 | 200 µg/ml | $357.00 | |||
PDE6H Antibody (G-2) Alexa Fluor® 647 | sc-398478 AF647 | 200 µg/ml | $357.00 | |||
PDE6H Antibody (G-2) Alexa Fluor® 680 | sc-398478 AF680 | 200 µg/ml | $357.00 | |||
PDE6H Antibody (G-2) Alexa Fluor® 790 | sc-398478 AF790 | 200 µg/ml | $357.00 |