PDE6D Antibody (E-7): sc-166854
- PDE6D Antibody (E-7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-150 representing full length PDE6D of human origin
- recommended for detection of PDE6D of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PDE6D Antibody (E-7) for WB applications. These reagents are now offered in bundles with PDE6D Antibody (E-7) (see ordering information below).
PDE6D Antibody (E-7) is a mouse monoclonal IgG2b antibody that detects phosphodiesterase 6D (PDE6D) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDE6D plays a crucial role in the visual signaling pathway, specifically in the phototransduction cascade, where PDE6D regulates cyclic guanosine monophosphate (cGMP) levels in photoreceptor cells. This regulation is vital for maintaining proper function of rod and cone cells in the retina, as alterations in cGMP levels can lead to impaired vision and various retinal disorders. PDE6D is a retina-specific oligomer composed of two catalytic chains (α and β), an inhibitory chain (γ), and the δ chain, which together ensure precise modulation of cGMP levels. PDE6D interacts with key proteins such as RPGR, ARL2, and ARL3, which are essential for function and stability. PDE6D contains two N-linked glycosylation sites, which are important for proper folding and activity, further underscoring the significance of post-translational modifications in the regulation of this critical enzyme.
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PDE6D Antibody (E-7) References:
- Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D). | Wang, W., et al. 1999. Gene. 236: 325-32. PMID: 10452952
- Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen. | Shepard, AR., et al. 2013. ACS Chem Biol. 8: 549-58. PMID: 23301619
- HIV-1 Matrix Protein p17 and its Receptors. | Caccuri, F., et al. 2016. Curr Drug Targets. 17: 23-32. PMID: 26302809
- PDE6D binds to the C-terminus of RPGR in a prenylation-dependent manner. | Lee, JJ. and Seo, S. 2015. EMBO Rep. 16: 1581-2. PMID: 26553938
- The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression. | Dietrich, P., et al. 2019. Cancers (Basel). 11: PMID: 30901922
- Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. | Teng, M., et al. 2022. J Med Chem. 65: 747-756. PMID: 34965125
- Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. | Yelland, T., et al. 2022. J Med Chem. 65: 1898-1914. PMID: 35104933
- PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia. | Faber, S., et al. 2023. Cells. 12: PMID: 36672247
- An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit KRAS Mutant Cancer Cell Growth. | Kaya, P., et al. 2024. J Med Chem. 67: 8569-8584. PMID: 38758695
- Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. | Li, N., et al. 1998. Genomics. 49: 76-82. PMID: 9570951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDE6D Antibody (E-7) | sc-166854 | 200 µg/ml | $322.00 | |||
PDE6D Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-537538 | 200 µg Ab; 10 µg BP | $361.00 | |||
PDE6D Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-534834 | 200 µg Ab; 40 µg BP | $361.00 | |||
PDE6D Antibody (E-7): m-IgG2b BP-HRP Bundle | sc-549887 | 200 µg Ab; 10 µg BP | $361.00 |