NPC2 Antibody (H-10): sc-166321

NPC2 Antibody (H-10) is a mouse monoclonal IgG2b antibody that detects Niemann-Pick disease, type C2 (NPC2) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NPC2 plays a crucial role in regulating lipid composition within sperm membranes during maturation in the epididymis, which is vital for proper sperm function and fertility. NPC2 is secreted and located in lysosomes, where NPC2 facilitates transport of cholesterol and other lipids, ensuring availability for cellular processes. Deficiencies or mutations in NPC2 can lead to Niemann-Pick type C2 disease, a severe hereditary condition characterized by impaired lysosomal cholesterol release, resulting in significant health issues such as frontal lobe atrophy. NPC2 is distinct from NPC1, as NPC1 retains HE1 protein, which is absent in NPC2-deficient fibroblasts, highlighting unique functional pathways and implications of NPC2 in lipid metabolism and disease pathology. Anti-NPC2 antibody (H-10) serves as an essential tool for researchers investigating molecular mechanisms underlying Niemann-Pick disease and related lipid disorders.

The preferred NPC2 antibody is NPC2 Antibody (D-3): sc-166449.