NPC2 Activators
NPC2, a critical player in cellular cholesterol trafficking and metabolism, is subject to modulation by a diverse array of chemical activators. Vorinostat, a histone deacetylase (HDAC) inhibitor, indirectly activates NPC2 by fostering lysosomal function through HDAC inhibition. This promotes NPC2 expression, contributing to its pivotal role in cholesterol transport and metabolism within the cellular milieu. U18666A, a cholesterol synthesis inhibitor, indirectly activates NPC2 by modulating intracellular cholesterol levels. Its influence on cholesterol synthesis triggers a cellular response that upregulates NPC2 expression, further establishing its involvement in cholesterol homeostasis. The liver X receptor (LXR) agonist, GW3965, indirectly activates NPC2 through the LXR pathway. By activating LXR, GW3965 enhances NPC2 transcription, ensuring its participation in cholesterol trafficking and cellular lipid homeostasis.
Genistein, an isoflavone, indirectly activates NPC2 through the AMP-activated protein kinase (AMPK) pathway, influencing NPC2 expression and its role in cellular cholesterol homeostasis. C75, a fatty acid synthase (FAS) inhibitor, indirectly activates NPC2 by modulating lipid metabolism and promoting NPC2 activity in the regulation of cellular lipids. Tamoxifen, a selective estrogen receptor modulator (SERM), indirectly activates NPC2 through estrogen receptor signaling, impacting NPC2 expression and its involvement in cholesterol metabolism. Betulinic Acid, a natural triterpenoid, indirectly activates NPC2 through the AMPK pathway, contributing to cellular cholesterol homeostasis. Luteolin, a flavonoid, indirectly activates NPC2 through the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, enhancing NPC2 expression and its role in cellular cholesterol homeostasis. Cysteamine, a cystine-depleting agent, indirectly activates NPC2 by influencing lysosomal function, promoting NPC2 activity in cholesterol transport and cellular lipid regulation. This diverse spectrum of NPC2 activators provides a comprehensive view of the intricate pathways and cellular processes that orchestrate the modulation of NPC2, shedding light on potential avenues for further exploration in the realm of cellular cholesterol homeostasis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $140.00 $483.00 $3121.00 | ||
GW3965, a liver X receptor (LXR) agonist, indirectly activates NPC2 through the LXR pathway. By activating LXR, GW3965 enhances the transcription of NPC2, promoting its role in cholesterol trafficking and maintaining cellular lipid homeostasis. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $53.00 $91.00 $169.00 $474.00 | 8 | |
25-Hydroxycholesterol, an oxysterol, indirectly activates NPC2 by modulating cholesterol metabolism. As an intermediate in cholesterol biosynthesis, it regulates NPC2 expression, facilitating its involvement in cholesterol transport and cellular lipid regulation. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone, a steroid hormone, indirectly activates NPC2 through the progesterone receptor pathway. By binding to its receptor, progesterone influences NPC2 expression, contributing to its role in regulating cellular cholesterol levels and lipid metabolism. | ||||||
Imipramine | 50-49-7 | sc-507545 | 5 mg | $190.00 | ||
Imipramine, a tricyclic antidepressant, indirectly activates NPC2 by affecting lysosomal function. It modulates lysosomal pH and integrity, leading to enhanced NPC2 activity and its participation in cholesterol trafficking and cellular lipid regulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, indirectly activates NPC2 through the AMP-activated protein kinase (AMPK) pathway. By activating AMPK, genistein influences NPC2 expression, contributing to its role in cellular cholesterol homeostasis and lipid metabolism. | ||||||
C75 (racemic) | 191282-48-1 | sc-202511 sc-202511A sc-202511B | 1 mg 5 mg 10 mg | $72.00 $206.00 $290.00 | 9 | |
C75, a fatty acid synthase (FAS) inhibitor, indirectly activates NPC2 by modulating lipid metabolism. By inhibiting FAS, C75 alters cellular lipid composition, promoting NPC2 activity and its involvement in cholesterol transport and regulation of cellular lipids. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen, a selective estrogen receptor modulator (SERM), indirectly activates NPC2 through estrogen receptor signaling. By interacting with estrogen receptors, tamoxifen influences NPC2 expression, contributing to its role in cholesterol metabolism and cellular lipid homeostasis. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid, a natural triterpenoid, indirectly activates NPC2 through the AMP-activated protein kinase (AMPK) pathway. By activating AMPK, betulinic acid influences NPC2 expression, contributing to its role in cellular cholesterol homeostasis and lipid metabolism. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin, a flavonoid, indirectly activates NPC2 through the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. By activating Nrf2, luteolin enhances NPC2 expression, contributing to its role in cellular cholesterol homeostasis and lipid metabolism. | ||||||
Cysteamine | 60-23-1 | sc-217991 sc-217991A sc-217991B | 5 g 25 g 50 g | $89.00 $238.00 $442.00 | 1 | |
Cysteamine, a cystine-depleting agent, indirectly activates NPC2 by influencing lysosomal function. By promoting lysosomal clearance and reducing oxidative stress, cysteamine enhances NPC2 activity, contributing to its role in cholesterol transport and cellular lipid regulation. | ||||||