Date published: 2025-9-5

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NPC1 Antibodies

Santa Cruz Biotechnology provides a broad selection of NPC1 monoclonal antibodies for various research applications. NPC1 monoclonal antibodies are suitable for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Niemann-Pick C1 (NPC1) is a crucial protein involved in lipid transport and cellular cholesterol homeostasis. NPC1 plays a significant role in the endosomal-lysosomal pathway, facilitating the movement of cholesterol from late endosomes to other cellular compartments. Dysregulation of NPC1 function is associated with Niemann-Pick disease and other metabolic disorders, making it a key focus in both basic and clinical research. Understanding NPC1's role in lipid metabolism has opened new avenues for investigating metabolic diseases and potential therapeutic interventions. Researchers can explore cellular cholesterol transport mechanisms and their impact on various pathological conditions. NPC1 monoclonal antibodies enable detailed examination of protein localization and function in different cellular compartments. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing our understanding of lipid metabolism and its role in human health.

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NPC1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

NPC1 Antibody (G-1)

sc-271335mouse IgA516-630 (h)WB, IP, IF, ELISAm, r, h
2
(3)

NPC1 Antibody (E-9)

sc-271334mouse IgG2a κ516-630 (h)WB, IP, IF, ELISAh

new

(1)

NPC1 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NPC1 CRISPR/Cas9 KO Plasmid (h)

sc-403252hGene KnockoutGFP
2
(0)

NPC1 HDR Plasmid (h)

sc-403252-HDRhHomology Directed RepairPuromycin
2
(0)

NPC1 Double Nickase Plasmid (h)

sc-403252-NIChGene KnockoutPuromycin
2
(0)

NPC1 Double Nickase Plasmid (h2)

sc-403252-NIC-2hGene KnockoutPuromycin
2
(0)

NPC1 CRISPR/Cas9 KO Plasmid (m)

sc-421941mGene KnockoutGFP0
(0)

NPC1 HDR Plasmid (m)

sc-421941-HDRmHomology Directed RepairPuromycin0
(0)

NPC1 Double Nickase Plasmid (m)

sc-421941-NICmGene KnockoutPuromycin0
(0)

NPC1 Double Nickase Plasmid (m2)

sc-421941-NIC-2mGene KnockoutPuromycin0
(0)

NPC1 CRISPR Activation Products

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NPC1 CRISPR Activation Plasmid (h)

sc-403252-ACThGene ActivationPuro, Blast, Hygro
2
(0)

NPC1 CRISPR Activation Plasmid (h2)

sc-403252-ACT-2hGene ActivationPuro, Blast, Hygro
2
(0)

NPC1 Lentiviral Activation Particles (h)

sc-403252-LAChGene ActivationPuro, Blast, Hygro
2
(0)

NPC1 Lentiviral Activation Particles (h2)

sc-403252-LAC-2hGene ActivationPuro, Blast, Hygro
2
(0)

NPC1 CRISPR Activation Plasmid (m)

sc-421941-ACTmGene ActivationPuro, Blast, Hygro0
(0)

NPC1 CRISPR Activation Plasmid (m2)

sc-421941-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

NPC1 Lentiviral Activation Particles (m)

sc-421941-LACmGene ActivationPuro, Blast, Hygro0
(0)

NPC1 Lentiviral Activation Particles (m2)

sc-421941-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

NPC1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NPC1 siRNA (h)

sc-41588hGene SilencingN/A
2
(0)

NPC1 shRNA Plasmid (h)

sc-41588-SHhGene SilencingPuromycin
2
(0)

NPC1 shRNA (h) Lentiviral Particles

sc-41588-VhGene SilencingPuromycin
2
(0)

NPC1 siRNA (m)

sc-41589mGene SilencingN/A
2
(0)

NPC1 shRNA Plasmid (m)

sc-41589-SHmGene SilencingPuromycin
2
(0)

NPC1 shRNA (m) Lentiviral Particles

sc-41589-VmGene SilencingPuromycin
2
(0)