NPC1 Activators
NPC1 (Niemann-Pick C1) protein is an integral membrane glycoprotein encoded by the NPC1 gene. It plays a crucial role in intracellular cholesterol trafficking and homeostasis. NPC1 is primarily located in late endosomes and lysosomes, where it facilitates the egress of cholesterol from these organelles to other cellular compartments, particularly the endoplasmic reticulum (ER) and the plasma membrane. This function is vital for maintaining cellular cholesterol levels and curbing the accumulation of cholesterol in the endo-lysosomal system. NPC1 achieves this by mediating the transport of cholesterol from the lumen of late endosomes and lysosomes to the cytoplasm, where it can be utilized for various cellular processes, including membrane synthesis and signaling.
Activation of NPC1 is a complex process involving multiple steps and regulatory mechanisms. One key aspect of NPC1 activation is its interaction with cholesterol and other lipids within the endo-lysosomal system. Cholesterol binding induces conformational changes in NPC1, facilitating its function in cholesterol efflux. Additionally, post-translational modifications such as glycosylation and phosphorylation may modulate NPC1 activity and localization within the cell. Furthermore, NPC1 activation is tightly regulated by intracellular signaling pathways and protein-protein interactions. For example, certain proteins, such as NPC2, have been identified as cofactors that enhance NPC1-mediated cholesterol transport. Moreover, cellular stressors and environmental cues can influence NPC1 activity through signal transduction pathways, ultimately affecting cellular cholesterol homeostasis. Overall, elucidating the precise mechanisms of NPC1 activation is essential for understanding its role in cholesterol metabolism and developing strategies for diseases associated with NPC1 dysfunction.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin is a statin that inhibits HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. By reducing cellular cholesterol levels, it can indirectly activate NPC1, as the protein is involved in cholesterol transport within lysosomes. | ||||||
GW3965 | 405911-09-3 | sc-490151 sc-490151A sc-490151B | 10 mg 50 mg 1 g | $260.00 $872.00 $1637.00 | ||
GW3965 is a synthetic liver X receptor (LXR) agonist. Activation of LXR has been implicated in promoting cholesterol efflux and regulating lipid homeostasis. NPC1, as a cholesterol transporter, may be influenced by increased cholesterol efflux. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone, a steroid hormone, has been associated with altered cholesterol metabolism. It may indirectly affect NPC1 by influencing cellular cholesterol levels and, subsequently, lysosomal cholesterol transport processes. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
T0901317 is a synthetic LXR agonist that modulates cholesterol metabolism. Activation of LXR by T0901317 may influence NPC1 function by regulating cholesterol homeostasis and transport within lysosomal compartments. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid has been explored for its potential in modulating lipid metabolism. Its indirect influence on NPC1 may be through alterations in cellular lipid profiles, affecting the protein's role in lysosomal cholesterol transport. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate is a fibrate class drug that activates peroxisome proliferator-activated receptor alpha (PPAR-α). PPAR-α activation can impact lipid metabolism, potentially influencing NPC1 function in the context of cholesterol transport. | ||||||
GW 9508 | 885101-89-3 | sc-203069 | 10 mg | $128.00 | ||
GW9508 is a selective agonist for peroxisome proliferator-activated receptor delta (PPAR-δ). Activation of PPAR-δ has been associated with lipid metabolism modulation, suggesting a potential indirect influence on NPC1 through altered lipid dynamics. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin is a flavonoid that has been linked to cholesterol metabolism modulation. Its effects on cholesterol levels may indirectly impact NPC1 function, given its role in lysosomal cholesterol transport and overall cellular lipid homeostasis. | ||||||