MHC class II Antibody (11-5.2): sc-53726

MHC class II Antibody (11-5.2) is a mouse monoclonal IgG2b antibody that detects MHC class II in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). MHC class II molecules play a crucial role in the immune response by presenting processed exogenous antigens to helper T lymphocytes, which are essential for orchestrating adaptive immunity. These molecules are primarily located on the surface of antigen-presenting cells, including B cells, dendritic cells, and macrophages, where they facilitate the recognition of foreign peptides. The ability of MHC class II to bind longer antigenic peptides, typically ranging from 13 to 18 amino acids, is vital for effective T cell activation and subsequent immune responses. The structural characteristics of MHC class II, including its non-covalent α and β chain composition, allow for a diverse range of peptide binding, which is essential for the immune system′s ability to recognize a wide variety of pathogens. Additionally, the regulation of peptide loading by molecules such as HLA-DM and HLA-DO ensures that only the most relevant antigens are presented to T cells, thereby enhancing the specificity and efficacy of the immune response. Anti-MHC class II antibody (11-5.2) is an invaluable tool for researchers studying immune mechanisms and the role of antigen presentation in various diseases.

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MHC class II Antibody (11-5.2) References:

1. Autophagy in MHC class II antigen processing.  |  Strawbridge, AB. and Blum, JS. 2007. Curr Opin Immunol. 19: 87-92. PMID: 17129719
2. Endosomal sorting of MHC class II determines antigen presentation by dendritic cells.  |  van Niel, G., et al. 2008. Curr Opin Cell Biol. 20: 437-44. PMID: 18582577
3. Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules.  |  Leddon, SA. and Sant, AJ. 2010. Curr Opin Organ Transplant. 15: 505-11. PMID: 20616724
4. Antigen Processing for MHC Class II Presentation via Autophagy.  |  Münz, C. 2012. Front Immunol. 3: 9. PMID: 22566895
5. A central role for HSC70 in regulating antigen trafficking and MHC class II presentation.  |  Deffit, SN. and Blum, JS. 2015. Mol Immunol. 68: 85-8. PMID: 25953005
6. IL-33 promotes MHC class II expression in murine mast cells.  |  Ito, T., et al. 2015. Immun Inflamm Dis. 3: 196-208. PMID: 26417437
7. The multifaceted roles of CD4+ T cells and MHC class II in cancer surveillance.  |  Bawden, E. and Gebhardt, T. 2023. Curr Opin Immunol. 83: 102345. PMID: 37245413
8. Expanding the role of MHC class II on intestinal epithelial cells.  |  Geuking, MB. 2023. Mucosal Immunol. 16: 548-550. PMID: 37286043
9. Assembly, transport, and function of MHC class II molecules.  |  Cresswell, P. 1994. Annu Rev Immunol. 12: 259-93. PMID: 8011283
10. Regulation of MHC class II genes: lessons from a disease.  |  Mach, B., et al. 1996. Annu Rev Immunol. 14: 301-31. PMID: 8717517

The preferred MHC class II antibody is MHC class II Antibody (IBL-5/22): sc-59322.