L-Selectin/CD62L/SELL Antibody (FMC46): sc-18918
- L-Selectin/CD62L/SELL Antibody (FMC46) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- raised against PHA stimulated lymphoblasts
- recommended for detection of L-Selectin of human origin by WB, IP, IF and FCM; also reactive with additional species, including and bovine, canine and monkey
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for L-Selectin/CD62L/SELL Antibody (FMC46) for WB applications. These reagents are now offered in bundles with L-Selectin/CD62L/SELL Antibody (FMC46) (see ordering information below).
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L-Selectin Antibody (FMC46) is a mouse monoclonal IgG2b light chain antibody that detects L-Selectin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). L-Selectin, also known as LECAM-1 or CD62L, plays a crucial role in the immune response by facilitating the adhesion of leukocytes to the endothelium, which is essential for their migration to sites of inflammation. L-Selectin (FMC46) monoclonal antibody recognizes a protein predominantly expressed on the surface of naive T cells, B cells, and various types of leukocytes, including monocytes, neutrophils, and eosinophils. L-Selectin′s ability to interact with specific carbohydrates on activated endothelial cells is vital for the recruitment of immune cells during inflammatory responses. Furthermore, L-Selectin′s interactions with other selectins, such as P-Selectin and E-Selectin, highlight its importance in mediating complex cellular interactions that are critical for maintaining immune homeostasis and responding to pathogens. Anti-L-Selectin antibody (FMC46) serves as an invaluable tool for researchers studying immune cell trafficking and the underlying mechanisms of inflammation.
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L-Selectin/CD62L/SELL Antibody (FMC46) References:
- Elevated serum L-selectin levels and decreased L-selectin expression on CD8(+) lymphocytes in systemic sclerosis. | Shimada, Y., et al. 2001. Clin Exp Immunol. 124: 474-9. PMID: 11472411
- Sulphated endothelial ligands for L-selectin in lymphocyte homing and inflammation. | van Zante, A. and Rosen, SD. 2003. Biochem Soc Trans. 31: 313-7. PMID: 12653627
- L-selectin: mechanisms and physiological significance of ectodomain cleavage. | Smalley, DM. and Ley, K. 2005. J Cell Mol Med. 9: 255-66. PMID: 15963248
- Sulfated L-selectin ligands as a therapeutic target in chronic inflammation. | Uchimura, K. and Rosen, SD. 2006. Trends Immunol. 27: 559-65. PMID: 17049924
- Role of c-Abl in L-selectin shedding from the neutrophil surface. | Ball, CJ. and King, MR. 2011. Blood Cells Mol Dis. 46: 246-51. PMID: 21277237
- Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. | Carlson, GE., et al. 2017. PLoS One. 12: e0173747. PMID: 28282455
- Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration. | Newe, A., et al. 2019. Front Immunol. 10: 2227. PMID: 31608057
- Increased L-Selectin on Monocytes Is Linked to the Autoantibody Profile in Systemic Sclerosis. | Brezovec, N., et al. 2022. Int J Mol Sci. 23: PMID: 35216350
- Influence of sE-selectin and L-selectin on the regulation of cell migration during chronic periodontitis. | Krugluger, W., et al. 1995. J Periodontal Res. 30: 198-203. PMID: 7473003
- The HNK-1 reactive sulfoglucuronyl glycolipids are ligands for L-selectin and P-selectin but not E-selectin. | Needham, LK. and Schnaar, RL. 1993. Proc Natl Acad Sci U S A. 90: 1359-63. PMID: 7679503
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Selectin/CD62L/SELL Antibody (FMC46) | sc-18918 | 200 µg/ml | $322.00 | |||
L-Selectin/CD62L/SELL Antibody (FMC46): m-IgG Fc BP-HRP Bundle | sc-536615 | 200 µg Ab; 10 µg BP | $361.00 | |||
L-Selectin/CD62L/SELL Antibody (FMC46): m-IgGκ BP-HRP Bundle | sc-533772 | 200 µg Ab; 40 µg BP | $361.00 | |||
L-Selectin/CD62L/SELL Antibody (FMC46): m-IgG2b BP-HRP Bundle | sc-549816 | 200 µg Ab; 10 µg BP | $361.00 | |||
L-Selectin/CD62L/SELL Antibody (FMC46) FITC | sc-18918 FITC | 200 µg/ml | $336.00 | |||
L-Selectin/CD62L/SELL Antibody (FMC46) PE | sc-18918 PE | 200 µg/ml | $349.00 |