L-Selectin Inhibitors
L-Selectin inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of L-Selectin, a cell adhesion molecule that plays a critical role in the immune system by mediating the adhesion and migration of leukocytes. L-Selectin, also known as CD62L, is a type I transmembrane protein expressed on the surface of most leukocytes, including lymphocytes, monocytes, and neutrophils. It functions by binding to carbohydrate ligands expressed on endothelial cells, particularly those in high endothelial venules (HEVs) of lymphoid tissues. This binding facilitates the tethering and rolling of leukocytes along the vascular endothelium, a key initial step in the process of leukocyte extravasation, where immune cells exit the bloodstream and enter tissues in response to inflammatory signals or during immune surveillance. By inhibiting L-Selectin, researchers can disrupt these critical adhesion events, providing a powerful tool to study the mechanisms of leukocyte trafficking, immune response, and inflammation.
In research settings, L-Selectin inhibitors are valuable tools for exploring the molecular mechanisms underlying leukocyte adhesion, migration, and the broader implications of these processes in immune function. By blocking L-Selectin activity, scientists can investigate how the inhibition affects leukocyte rolling, adhesion, and subsequent transmigration across the endothelium into tissues. This can lead to a deeper understanding of how immune cells are recruited to sites of inflammation or injury and the role of L-Selectin in maintaining immune surveillance in lymphoid tissues. Additionally, L-Selectin inhibitors allow researchers to study the interactions between L-Selectin and its ligands, providing insights into the specific carbohydrate structures required for effective binding and the modulation of these interactions under different physiological conditions. Through these studies, the use of L-Selectin inhibitors enhances our knowledge of cell adhesion molecules, the regulation of leukocyte trafficking, and the intricate processes that control immune cell movement and positioning within the body.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Fingolimod is a sphingosine-1-phosphate receptor modulator that can influence lymphocyte trafficking. By modulating S1P receptors, Fingolimod indirectly impacts the migration and activation of immune cells, including those expressing L-Selectin. This compound may offer insights into the regulation of L-Selectin through altered lymphocyte trafficking dynamics. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis toxin, found in Bordetella pertussis, disrupts G protein signaling. As L-Selectin is associated with G protein-coupled receptors, such as chemokine receptors, Pertussis toxin may indirectly modulate L-Selectin function by interfering with G protein-mediated signaling pathways. Researchers can utilize this toxin to explore the intricate connections between G protein signaling and L-Selectin expression and activation. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin, an HMG-CoA reductase inhibitor, is primarily known for its cholesterol-lowering effects. However, it also exhibits immunomodulatory properties. By affecting the mevalonate pathway, Lovastatin can indirectly influence immune cell function, potentially impacting the regulation of L-Selectin. Researchers can explore the connection between cholesterol metabolism, mevalonate pathway activity, and L-Selectin expression using this compound. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor that can impact signaling pathways crucial for immune cell activation and migration. By inhibiting PI3K, Wortmannin may indirectly influence L-Selectin-mediated processes, such as leukocyte adhesion and rolling. This compound provides a tool to dissect the role of PI3K signaling in the regulation of L-Selectin and its involvement in immune cell trafficking. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine, a calcium channel blocker, may indirectly modulate L-Selectin through its impact on intracellular calcium levels. Calcium signaling plays a role in immune cell activation and adhesion processes, and Amlodipine provides a tool to investigate the link between calcium dynamics and L-Selectin function. Researchers can explore how calcium channel blockade affects L-Selectin-mediated immune cell responses using this compound. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can influence MAPK signaling pathways. As MAPKs are involved in cellular responses to inflammation and immune activation, SB203580 may indirectly modulate L-Selectin-mediated processes. Researchers can utilize this compound to dissect the role of p38 MAPK in the regulation of L-Selectin and its impact on immune cell adhesion and trafficking. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib is a Janus kinase (JAK) inhibitor that affects cytokine signaling. Given the role of cytokines in immune cell activation and migration, Ruxolitinib may indirectly impact L-Selectin function. This compound provides a tool to investigate the connections between JAK-STAT signaling, cytokine responses, and L-Selectin-mediated immune cell adhesion and trafficking. | ||||||
Lenvatinib | 417716-92-8 | sc-488530 sc-488530A sc-488530B | 5 mg 25 mg 100 mg | $182.00 $661.00 $1690.00 | 3 | |
TGF-β Receptor Inhibitor VI targets the TGF-β signaling pathway, which plays a role in immune regulation. By inhibiting TGF-β receptor activity, this compound may indirectly influence L-Selectin-mediated processes in immune cells. Researchers can use TGF-β Receptor Inhibitor VI to explore the impact of TGF-β signaling on L-Selectin regulation and immune cell trafficking dynamics. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine, a phosphodiesterase (PDE) inhibitor, may indirectly impact L-Selectin function by affecting intracellular cAMP levels. PDE inhibition leads to increased cAMP, influencing cellular responses. Researchers can explore the role of cAMP signaling in L-Selectin-mediated processes using Vinpocetine as a tool to dissect the connections between PDE activity, cAMP levels, and L-Selectin regulation in immune cells. | ||||||