Pertussis Toxin (islet-activating protein) CAS: 70323-44-3
A toxin that blocks reduction of adenylate cyclase activity.

Pertussis Toxin (islet-activating protein) (CAS 70323-44-3)

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同義語 PTX;Holotoxin
アプリケーション: A toxin that blocks reduction of adenylate cyclase activity
CAS 番号: 70323-44-3
Purity: >99%
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pertussis Toxin (islet-activating protein), a toxin originally isolated from Bordetella pertussis, has been shown to catalyze ADP-ribosylation of a protein in membrane preparation from rat C6 glioma cells. In addition, exposure of Chinese hamster ovary cells in culture to this compound has resulted in a clustered growth pattern response. Other experiments have shown Pertussis Toxin to block the ability of inhibitory hormones to reduce adenylate cyclase activity and enhance the ability of stimulatory hormones to activate the enzyme. Mechanistic studies have shown this toxin to consist of subunit A (active) promoter, which disrupts transmembrane signaling by ADP-ribosylating eukaryotic G-proteins, and B (binding) oligomer which helps the toxin bind to cells in vivo.


参考文献

1. Tamura, M., et al. 1982. Biochemistry. 21: 5516-5522. PMID: 6293544
2. Hewlett, E.L., et al. 1983. Infect. Immun. 40: 1198-1203. PMID: 6682833
3. Bokoch, G.M., et al. 1983. J. Biol. Chem. 258: 2072-2075. PMID: 6296122
4. Kaslow, H.R., et al. 1987. Biochemistry. 26: 123-127. PMID: 3030399
5. Kaslow, H.R. and Burns, D.L. 1992. FASEB J. 6: 2684-2690. PMID: 1612292

Physical State :
Solid
Derived From :
Bordetella pertussis
Solubility :
Soluble in water (Miscible).
保存方法 :
Store at 4° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
XW5883750
MDL Number :
MFCD00131841

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Pertussis Toxin (islet-activating protein)  参考文献

See how others have used Pertussis Toxin (islet-activating protein). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 3158374  Fujita, N. et al. 1985. Brain Res. 333: 231-236.

Citations 1 to 1 of 1 total
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