IL-4 Antibody (8D4-8): sc-53710
- IL-4 Antibody (8D4-8) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant full length IL-4 of human origin
- recommended for detection of IL-4 of human origin by FCM and ELISA
- See IL-4 (HIL44): sc-13555 for IL-4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-4 Antibody (8D4-8). These reagents are now offered in bundles with IL-4 Antibody (8D4-8) (see ordering information below).
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SEE ALSO...
IL-4 Antibody (8D4-8) is a mouse monoclonal IgG1 antibody that detects interleukin-4 (IL-4) in human samples through applications such as flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA). IL-4 is a crucial glycosylated cytokine secreted primarily by activated T lymphocytes, basophils, and mast cells, playing a significant role in the immune response by promoting the growth and differentiation of immune cells. One of the key functions of IL-4 is inducing immunoglobulin class switching, which is vital for the adaptive immune system′s ability to produce antibodies tailored to specific pathogens. This process is particularly important as IL-4 stimulates B cells to produce immunoglobulin E (IgE) and enhances the secretion of immunoglobulin G4 (IgG4), while simultaneously suppressing the production of other immunoglobulin classes such as IgM, IgA, IgG1, IgG2, and IgG3. The regulation of these immunoglobulin classes is essential for maintaining a balanced immune response, especially in allergic reactions and responses to parasitic infections. Anti-IL-4 antibody (8D4-8) serves as an invaluable tool for researchers studying the intricate mechanisms of immune regulation and the role of cytokines in various diseases.
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IL-4 Antibody (8D4-8) References:
- IL-4 and many roads to lupuslike autoimmunity. | Singh, RR. 2003. Clin Immunol. 108: 73-9. PMID: 12921752
- Allergic inflammation: role of cytokines with special emphasis on IL-4. | Saggini, A., et al. 2011. Int J Immunopathol Pharmacol. 24: 305-11. PMID: 21658305
- FRNK negatively regulates IL-4-mediated inflammation. | Sharma, R., et al. 2015. J Cell Sci. 128: 695-705. PMID: 25501808
- IL-4 enhances expression and function of surface IgM in CLL cells. | Aguilar-Hernandez, MM., et al. 2016. Blood. 127: 3015-25. PMID: 27002119
- IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling. | Skaria, T., et al. 2016. PLoS One. 11: e0156002. PMID: 27214384
- IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints. | Panda, SK., et al. 2020. Proc Natl Acad Sci U S A. 117: 3103-3113. PMID: 31980518
- STAT3 determines IL-4 signalling outcomes in naïve T cells. | Deimel, LP., et al. 2021. Sci Rep. 11: 10495. PMID: 34006897
- Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection. | Ghorbani, P., et al. 2023. PLoS Pathog. 19: e1011658. PMID: 37747879
- IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4. | Hils, M., et al. 2024. J Allergy Clin Immunol. 153: 1050-1062.e6. PMID: 38135009
- Expression of miR-21 &IL-4 in endometriosis. | Sadat Sandoghsaz, R., et al. 2024. Hum Immunol. 85: 110746. PMID: 38155071
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-4 Antibody (8D4-8) | sc-53710 | 200 µg/ml | $322.00 | |||
IL-4 Antibody (8D4-8): m-IgG Fc BP-HRP Bundle | sc-536997 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-4 Antibody (8D4-8): m-IgGκ BP-HRP Bundle | sc-534177 | 200 µg Ab; 40 µg BP | $361.00 | |||
IL-4 Antibody (8D4-8): m-IgG1 BP-HRP Bundle | sc-544948 | 200 µg Ab; 20 µg BP | $361.00 |