IL-4 Antibody (HIL44): sc-13555
- IL-4 Antibody (HIL44) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against full length IL-4 of human origin
- recommended for detection of IL-4 of human origin by WB, IP and ELISA
- Anti-IL-4 Antibody (HIL44) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-4 Antibody (HIL44) for WB applications. These reagents are now offered in bundles with IL-4 Antibody (HIL44) (see ordering information below).
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SEE ALSO...
IL-4 Antibody (HIL44) is a mouse monoclonal IgG1 kappa light chain antibody that detects Interleukin-4 (IL-4) of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IL-4 Antibody (HIL44) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-4, also known as B cell stimulatory factor-1, is a glycosylated cytokine secreted primarily by activated T lymphocytes, basophils, and mast cells. IL-4 plays a crucial role in the immune system by promoting the growth and differentiation of immune cells, particularly by enhancing the Th2 cell lineage while suppressing Th1 responses. IL-4′s importance extends to inducing immunoglobulin class switching, which is vital for effective immune responses. Specifically, IL-4 stimulates B cells to produce immunoglobulin E (IgE) and enhances the secretion of immunoglobulin G4 (IgG4), while simultaneously inhibiting the production of other immunoglobulin classes such as IgM, IgA, IgG1, IgG2, and IgG3. The regulation of these immunoglobulin classes is essential for maintaining a balanced immune response and preventing allergic reactions. Additionally, the signaling pathway activated by IL-4 involves the rapid tyrosine phosphorylation of Stat6, a transcription factor that mediates the effects of IL-4, highlighting the intricate mechanisms through which IL-4 influences immune function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-4 Antibody (HIL44) References:
- Strategies targeting the IL-4/IL-13 axes in disease. | May, RD. and Fung, M. 2015. Cytokine. 75: 89-116. PMID: 26255210
- Basophil-derived IL-4 plays versatile roles in immunity. | Yamanishi, Y. and Karasuyama, H. 2016. Semin Immunopathol. 38: 615-22. PMID: 27160724
- Targeting IL-4 for the Treatment of Atopic Dermatitis. | Chiricozzi, A., et al. 2020. Immunotargets Ther. 9: 151-156. PMID: 33062619
- IL-4 expressing cells are recruited to nerve after injury and promote regeneration. | Pan, D., et al. 2022. Exp Neurol. 347: 113909. PMID: 34717939
- Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling. | Luan, D., et al. 2023. Diabetes. 72: 367-374. PMID: 36449000
- IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation. | Zhou, T., et al. 2022. Cell Death Dis. 13: 1056. PMID: 36539414
- Association of IL-4 with pachychoroid neovasculopathy. | Baba, T., et al. 2023. Sci Rep. 13: 1152. PMID: 36670145
- Requirements of IL-4 during the Generation of B Cell Memory. | Chakma, CR. and Good-Jacobson, KL. 2023. J Immunol. 210: 1853-1860. PMID: 37276051
- IL-4 Licenses B Cell Activation Through Cholesterol Synthesis. | Steach, HR., et al. 2024. bioRxiv.. PMID: 38798553
- IL-4 promotes immunotherapy resistance. | Jauregui, P. 2024. Nat Immunol. 25: 2169. PMID: 39587344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-4 Antibody (HIL44) | sc-13555 | 200 µg/ml | $322.00 | |||
IL-4 Antibody (HIL44): m-IgG Fc BP-HRP Bundle | sc-536576 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-4 Antibody (HIL44): m-IgGκ BP-HRP Bundle | sc-533727 | 200 µg Ab; 40 µg BP | $361.00 | |||
IL-4 Antibody (HIL44): m-IgG1 BP-HRP Bundle | sc-544687 | 200 µg Ab; 20 µg BP | $361.00 | |||
IL-4 Antibody (HIL44) AC | sc-13555 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IL-4 Antibody (HIL44) HRP | sc-13555 HRP | 200 µg/ml | $322.00 | |||
IL-4 Antibody (HIL44) FITC | sc-13555 FITC | 200 µg/ml | $336.00 | |||
IL-4 Antibody (HIL44) PE | sc-13555 PE | 200 µg/ml | $349.00 | |||
IL-4 Antibody (HIL44) Alexa Fluor® 488 | sc-13555 AF488 | 200 µg/ml | $364.00 | |||
IL-4 Antibody (HIL44) Alexa Fluor® 546 | sc-13555 AF546 | 200 µg/ml | $364.00 | |||
IL-4 Antibody (HIL44) Alexa Fluor® 594 | sc-13555 AF594 | 200 µg/ml | $364.00 | |||
IL-4 Antibody (HIL44) Alexa Fluor® 647 | sc-13555 AF647 | 200 µg/ml | $364.00 | |||
IL-4 Antibody (HIL44) Alexa Fluor® 680 | sc-13555 AF680 | 200 µg/ml | $364.00 | |||
IL-4 Antibody (HIL44) Alexa Fluor® 790 | sc-13555 AF790 | 200 µg/ml | $364.00 |