GADD 34 Antibody (D-8): sc-46661
- GADD 34 Antibody (D-8) is a mouse monoclonal IgG2a κ, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 483-674 of GADD 34 of human origin
- recommended for detection of GADD 34 of human origin by WB, IP, IF and ELISA
- See GADD 34 (B-10): sc-373815 for GADD 34 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GADD 34 Antibody (D-8) for WB applications. These reagents are now offered in bundles with GADD 34 Antibody (D-8) (see ordering information below).
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GADD 34 Antibody (D-8) is a mouse monoclonal IgG2a antibody that detects GADD 34 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GADD 34, also known as MyD116, plays a crucial role in the cellular response to DNA damage by promoting the dephosphorylation of eIF2α, which is essential for regulating protein synthesis during stress conditions. This function helps restore normal cellular functions and prevent the accumulation of damaged proteins, thereby maintaining cellular homeostasis and preventing tumorigenesis. Elevated levels of GADD 34 have been associated with various cancers, indicating potential as a biomarker for tumor progression and a target for therapeutic intervention. Anti-GADD 34 antibody (D-8) serves as an invaluable tool for researchers studying the mechanisms of DNA damage response and the role of GADD 34 in cell cycle regulation and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GADD 34 Antibody (D-8) References:
- Female GADD34 mice develop age-related inflammation and hepatocellular carcinoma. | Nishio, N., et al. 2017. Geriatr Gerontol Int. 17: 2593-2601. PMID: 28635009
- GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition. | Ishaq, M., et al. 2020. Virology. 540: 119-131. PMID: 31778897
- GADD34 is a modulator of autophagy during starvation. | Gambardella, G., et al. 2020. Sci Adv. 6: PMID: 32978159
- Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation. | Li, H., et al. 2022. Microbiol Spectr. 10: e0138821. PMID: 34985336
- GADD34 suppresses eIF2α phosphorylation and improves cognitive function in Alzheimer's disease-model mice. | Hayakawa-Ogura, M., et al. 2023. Biochem Biophys Res Commun. 654: 112-119. PMID: 36907138
- GADD34 activates p53 and may have utility as a marker of atherosclerosis. | Tomiyoshi, G., et al. 2023. Front Med (Lausanne). 10: 1128921. PMID: 37228401
- The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP). | Hicks, D., et al. 2023. Int J Mol Sci. 24: PMID: 38139150
- The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation. | Oliveira, MM., et al. 2024. Cell Rep. 43: 113670. PMID: 38219147
- Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress. | Magg, V., et al. 2024. Cell Rep. 43: 114069. PMID: 38602876
- SARS-CoV-2 Nucleocapsid Protein Antagonizes GADD34-Mediated Innate Immune Pathway through Atypical Foci. | Liu, J., et al. 2024. Molecules. 29: PMID: 39459161
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GADD 34 Antibody (D-8) | sc-46661 | 200 µg/ml | $322.00 | |||
GADD 34 Antibody (D-8): m-IgG Fc BP-HRP Bundle | sc-536787 | 200 µg Ab; 10 µg BP | $361.00 | |||
GADD 34 Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-533951 | 200 µg Ab; 40 µg BP | $361.00 | |||
GADD 34 Antibody (D-8): m-IgG2a BP-HRP Bundle | sc-547871 | 200 µg Ab; 10 µg BP | $361.00 |