ERK 3 Antibody (G-2): sc-393371
- ERK 3 Antibody (G-2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 304-339 within subdomain XI of ERK 3 of rat origin
- recommended for detection of ERK 3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ERK 3 Antibody (G-2) for WB applications. These reagents are now offered in bundles with ERK 3 Antibody (G-2) (see ordering information below).
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ERK 3 Antibody (G-2) is a mouse monoclonal IgG2b antibody that detects ERK 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERK 3, also known as PRKM6 or p97MAPK, plays a crucial role in mitogen-activated protein kinase (MAPK) signaling pathways, which are essential for various cellular processes, including growth, differentiation, and response to stress. Notably, ERK 3 is constitutively localized to the nucleus upon activation, despite the absence of a definitive nuclear localization sequence, highlighting ERK 3′s importance in mediating intracellular defense mechanisms. The human ERK 3 gene is located on chromosome 15q21.2 and encodes a 721 amino acid protein involved in upregulating signaling pathways independent of p53, Bcl-2, and caspase-3 during cellular stress induced by proteasome inhibition. This suggests ERK 3 may play a significant role in cell survival and rescue, making ERK 3 a vital target for research in cancer and other diseases where cell signaling is disrupted. Anti-ERK 3 antibody (G-2) serves as an invaluable tool for researchers exploring the intricate dynamics of MAPK signaling and its implications in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERK 3 Antibody (G-2) | sc-393371 | 200 µg/ml | $316.00 | |||
ERK 3 Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-535765 | 200 µg Ab; 40 µg BP | $354.00 | |||
ERK 3 Antibody (G-2): m-IgG2b BP-HRP Bundle | sc-549477 | 200 µg Ab; 10 µg BP | $354.00 | |||
ERK 3 (G-2) Neutralizing Peptide | sc-393371 P | 100 µg/0.5 ml | $68.00 |