ERK 3 Activators
Extracellular signal-regulated kinase 3 (ERK3) is a member of the mitogen-activated protein kinase (MAPK) family, which plays a pivotal role in regulating diverse cellular processes, including cell proliferation, differentiation, and response to stress. Unlike its more extensively studied counterparts, ERK1 and ERK2, the functions and regulatory mechanisms of ERK3 are less well-characterized, partly due to its unique structural features and activation mechanisms. ERK3 is distinct in that it possesses a serine/threonine kinase activity and is activated through mechanisms that do not entirely conform to the classical MAPK activation cascade. This kinase is implicated in various cellular functions through its ability to phosphorylate a range of substrates, thereby influencing cellular dynamics and homeostasis.
The activation of ERK3 is intricately linked to cellular responses to environmental and physiological stressors. This involves a complex network of upstream regulators and downstream effectors that mediate its activation and functional outcomes. Among the key mechanisms underlying ERK3 activation are interactions with specific phosphatases and kinases that modulate its phosphorylation state, affecting its stability and activity. Additionally, ERK3 has been shown to interact with scaffold proteins and cellular organelles, further influencing its role in cellular signaling pathways. The functional activation of ERK3 is critical for the regulation of gene expression, cytoskeletal reorganization, and metabolic processes, underscoring its importance in maintaining cellular adaptability and survival. Through its involvement in these processes, ERK3 contributes to the cellular defense mechanisms against oxidative stress, inflammation, and other challenges, highlighting its potential as a target for modulating cellular responses to stress and disease states.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has been shown to activate ERK3 via its antioxidant properties, leading to reduced oxidative stress in cells. This activation can enhance cellular defense mechanisms against environmental stressors, indirectly promoting ERK3 activation as part of the cell’s response to mitigate damage. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes, activates ERK3 by modulating upstream kinases within the MAPK pathway. This activation is crucial for the regulation of cellular processes such as proliferation and apoptosis, where ERK3 plays a significant role in mediating cellular responses to resveratrol. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, the active ingredient in turmeric, has been found to activate ERK3 by influencing its phosphorylation status. The compound's anti-inflammatory and antioxidant properties contribute to its ability to enhance ERK3 activation, which is pivotal in cell survival and stress response pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a compound in cruciferous vegetables, activates ERK3 through its role in detoxification and antioxidant defense mechanisms. This chemical induces Nrf2 pathway activation, which is closely related to ERK3 activation, enhancing cellular resistance to oxidative stress. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, the active component of chili peppers, activates ERK3 by interacting with sensory neurons and modulating intracellular calcium levels. This interaction stimulates cellular pathways leading to ERK3 activation, which is involved in pain and inflammatory response regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in many fruits and vegetables, activates ERK3 by modulating antioxidant defense mechanisms. Its ability to scavenge free radicals and reduce oxidative stress indirectly promotes ERK3 activation, aiding in cellular protection and stress response. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine stimulates ERK3 activation by antagonizing adenosine receptors, which leads to the modulation of cyclic AMP levels and activation of PKA. This cascade ultimately contributes to the activation of ERK3, influencing cellular energy metabolism and stress response mechanisms. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid, or vitamin C, activates ERK3 by reducing oxidative stress and enhancing the cellular antioxidant capacity. This mechanism supports the activation of ERK3, contributing to its role in cellular defense against environmental stressors. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Sulphate enhances ERK3 activation through modulation of cellular signaling pathways involved in inflammation and immune response. By supporting the function of various enzymes, it indirectly contributes to the activation of ERK3, playing a role in cellular defense mechanisms. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine activates ERK3 by acting as a precursor for glutathione, thus enhancing cellular antioxidant defenses. This supports the activation of ERK3 in response to oxidative stress, playing a crucial role in maintaining cellular integrity and response to environmental challenges. | ||||||