(-)-Epigallocatechin Gallate CAS: 989-51-5
MF: C22H18O11
MW: 458.37
An inhibitor of Bcl-2 and NOS2.

(−)-Epigallocatechin Gallate (CAS 989-51-5)

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同义词: EGCG; Teavigo
应用; An inhibitor of Bcl-2 and NOS2
CAS号码: 989-51-5
纯度: ≥98%
分子量: 458.37
分子式: C22H18O11
* 参考分析证明 大量特定数据 (包括水 含量).
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(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).


参考文献

1. Miura, S., et al., 1995. Effects of various natural antioxidants on the Cu(2+)-mediated oxidative modification of low density lipoprotein. Biological & pharmaceutical bulletin. 18(1): 1-4. PMID: 7735221
2. Cherbonnel-Lasserre, C., et al., 1997. Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage. Biochimie. 79(9-10): 613-7. PMID: 9466700
3. Lu, L H., et al., 1998. Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK. British journal of pharmacology. 124(6): 1227-37. PMID: 9720795
4. Paschka, A G., et al., 1998. Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate. Cancer letters. 130(1-2): 1-7. PMID: 9751250
5. Nakagawa, Hiroshi., et al., 2002. Fenton reaction is primarily involved in a mechanism of (-)-epigallocatechin-3-gallate to induce osteoclastic cell death. Biochemical and biophysical research communications. 292(1): 94-101. PMID: 11890677
6. Nakagawa, Takako., et al., 2002. Protective activity of green tea against free radical- and glucose-mediated protein damage. Journal of agricultural and food chemistry. 50(8): 2418-22. PMID: 11929306
7. Nakagawa, T., et al., 2002. Direct scavenging of nitric oxide and superoxide by green tea. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 40(12): 1745-50. PMID: 12419687
8. Leone, Marilisa., et al., 2003. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer research. 63(23): 8118-21. PMID: 14678963
9. Itabe, Hiroyuki., et al., 2009. Oxidative modification of LDL: its pathological role in atherosclerosis. Clinical reviews in allergy & immunology. 37(1): 4-11. PMID: 18987785

物理状态 :
Solid
溶解度 :
Soluble in ethanol (~20 mg/ml), dimethyl formamide (~20 mg/ml), DMSO (~20 mg/ml), water (>5 mg/ml), DMF, PBS pH 7.2, and Methanol.
保存 :
Store at -20° C
熔点 :
315.59° C (Predicted)
沸点 :
~909.11° C at 760 mmHg (Predicted)
密度 :
~1.90 g/cm3 (Predicted)
折射率 :
n20D 1.86
光学活性 :
α20/D -175.5°, c = 1 in ethanol
IC50 :
6-phosphogluconate dehydrogenase: IC50 = 720 nM (human); Human herpesvirus 1: IC50 = 18300 nM; Fatty acid synthase: IC50 = 0.03 µg/ml (Plasmodium falciparum); 3-oxoacyl-acyl-carrier protein reductase: IC50 = 0.32 µg/ml (Plasmodium falciparum); Human immunodeficiency virus 1: IC50 = 19910 nM
pK值 :
pKa: 7.75
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
KB5200000
PubChem CID :
65064
默克索引 :
14: 3526
MDL 号码 :
MFCD00075940
EC号码 :
479-560-7
Beilstein 注册 :
3658838
SMILES :
C1[[email protected]]([[email protected]](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

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PMID: # 29122665  Ferreira, A. et al. 2017. Food Chem. Toxicol. 111: 84-93.

PMID: # 28115242  Jeong, CH.|Seok, JS.|Petriello, MC.|Han, SG.| et al. 2017. Toxicology. 379: 31-39.

PMID: # 27356022  Wang, T. et al. 2016. Biochemistry. 55: 4036-46.

PMID: # 25534770  Cook, I. et al. 2015. Drug metabolism and disposition: the biological fate of chemicals. 43: 418-23.

PMID: # 23448667  Bruchmann, A. et al. 2013. BMC Cancer. 13: 96.

PMID: # 18687687  Shim, JH. et al. 2008. J. Biol. Chem. 283: 28370-28379.

PMID: # 14559356  Koh, SH. et al. 2003. Brain Res. Mol. Brain Res. 118: 72-81.

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