Resveratrol CAS: 501-36-0
MF: C14H12O3
MW: 228.24
A natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1.

Resveratrol (CAS 501-36-0)

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同义词: Trans-3,4′,5-Trihydroxystilbene; 1,3-Benzenediol, 5-[2-(4-hydroxyphenyl)ethenyl]-
应用; A natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1
CAS号码: 501-36-0
纯度: ≥98%
分子量: 228.24
分子式: C14H12O3
* 参考分析证明 大量特定数据 (包括水 含量).
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Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenol derived from red wine; in Asian folk-medicine it and it′s glycoside, polydatin (sc-203203) are the primary ingredients of Kojo-Kon (derived from the dried root of Japanese knotweed). This trihydroxystilbene is derived from various sources and has been studied with regard to numerous applications including reducing serum lipids, inhibition of platelet aggregation, and actions as a chemopreventative agent and antioxidant. Resveratrol has been shown to increase the longevity of yeast and to display antiproliferative effects on cancer stem cells in vitro. Resveratrol is a specific inhibitor of Cox-1 (cyclooxygenase-1) via inhibition of the hydroperoxidase activity of Cox-1.

Resveratrol has also been used extensively in stem cell studies to enhance self-renewal and multipotency of mesencymal stem cells (MSC′s) in vitro. Numerous studies have been conducted with regard to resveratrol-modified cardiac stem cells enhancing cardiac healing in vitro. Similar studies with bone marrow derived stem cells (BMSCs) have shown that resveratrol acts as a NF-κB inhibitor to protect MSC-derived chondrocytes in vitro. Additional research with resveratrol used to treat adipose-derived mesenchymal stem cells (ADMSCs) resulted in increased alkaline phosphatase activity and osteocalcin levels; thus enriching the MSC and osteoprogenitor cell populations in cultured ADMSCs in vitro.


参考文献

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3. Fontecave, M., et al. 1998. FEBS Lett. 421: 277-279. PMID: 9468322
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5. Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262: 20-24. PMID: 10448061
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7. Frémont, L., 2000. Life Sci. 66: 663-673. PMID: 10680575
8. Kimura, Y., 2003. Methods Find Exp Clin Pharmacol. 25: 297-310. PMID: 12808475
9. Howitz, K.T., et al. 2003. Nature. 425: 191-196. PMID: 12939617
10. Baur, J.A. and Sinclair, D.A. 2006. Nat Rev Drug Discov. 5: 493-506. PMID: 16732220
11. Lei, M., et al. 2008. Acta Pharmacol. Sin. 29: 1350-1356. PMID: 18954530
12. Pandey, P.R., et al. 2010. Breast Cancer Res Treat. PMID: 21188630
13. Gurusamy, N., et al. 2010. J. Cell. Mol. Med. 14: 2235-2239. PMID: 20716127
14. Kao, C.L., et al. 2010. Stem Cells Dev. 19: 247-258. PMID: 19656070

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (≥16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL).
保存 :
Store at -20° C
熔点 :
253-255° C
沸点 :
449.12° C at 760 mmHg (Predicted)
密度 :
1.36 g/cm3 (Predicted)
折射率 :
n20D 1.76 (Predicted)
IC50 :
cytochrome P450 1A1: IC50 = 23 µM; PKD in vitro: IC50 = 200 µM; PKD in vivo: IC50 = 800 µM; Cytochrome P450 2C19: IC50 = 3 µM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 36.3 µM (human); Cyclooxygenase-1: IC50 = 535 nM (Ovis aries); Monoamine oxidase A: IC50 = 449 nM (human)
pK值 :
pKa: 9.22 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
CZ8987000
PubChem CID :
5056
默克索引 :
14: 8158
MDL 号码 :
MFCD00133799
EC号码 :
610-504-8
Beilstein 注册 :
1912434
SMILES :
C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

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PMID: # 31040579  Al-Tamimi, H.|Al-Dawood, A.|Awaishesh, S.|Abdalla, T.| et al. 2019. Vet World. 12: 337-344.

PMID: # 29906565  Nøhr-Meldgaard, K. et al. 2018. Int. J. Antimicrob. Agents. 52: 390-396.

PMID: # 29958542  Furat Rencber, S.|Kurnaz Ozbek, S.|Eraldemır, C.|Sezer, Z.|Kum, T.|Ceylan, S.|Guzel, E.| et al. 2018. J Ovarian Res. 11: 55.

PMID: # 28750181  2018. Connect. Tissue Res. 59: 245-254.

PMID: # 27771282  Kaur, M. et al. 2017. Brain Res. 1654: 9-23.

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 28915620  Islam, SU. et al. 2017. Oncotarget. 8: 56659-56671.

PMID: # 27129153  Labay, E. et al. 2016. Oncotarget.

PMID: # 26870238  Xiong, W. et al. 2016. Oncol Lett. 11: 484-490.

PMID: # 27634755  Allain, C. et al. 2016. Cancer Res. 76: 6374-6381.

引用1 - 1021
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