ERK 3 Antibody (E-3): sc-374239
- ERK 3 Antibody (E-3) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 565-721 mapping at the C-terminus of ERK 3 of human origin
- recommended for detection of ERK 3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ERK 3 Antibody (E-3) for WB and IHC(P) applications. These reagents are now offered in bundles with ERK 3 Antibody (E-3) (see ordering information below).
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ERK 3 Antibody (E-3) is a mouse monoclonal IgG1 antibody that detects ERK 3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERK 3, also known as PRKM6 or p97MAPK, plays a crucial role in mitogen-activated protein kinase (MAPK) signaling pathways, which are essential for regulating cellular responses to growth factors and stress signals. Anti-ERK 3 antibody (E-3) is involved in mediating intracellular defense mechanisms, particularly during cell stress induced by proteasome inhibition, where ERK 3 upregulation occurs independently of p53, Bcl-2, and caspase-3 status. This suggests ERK 3 may contribute to cell survival and rescue processes under adverse conditions. The human ERK 3 gene is located on chromosome 15q21.2 and encodes a protein consisting of 721 amino acids, which is vital for various cellular functions. ERK 3′s ability to localize to the nucleus upon activation, despite the absence of a definitive nuclear localization sequence, underscores its importance in cellular signaling and response mechanisms. With broad species reactivity and multiple applications, ERK 3 monoclonal antibody (E-3) serves as an invaluable tool for researchers studying MAPK pathways and their implications in health and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ERK 3 Antibody (E-3) References:
- ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. | Long, W., et al. 2012. J Clin Invest. 122: 1869-80. PMID: 22505454
- ERK3 promotes endothelial cell functions by upregulating SRC-3/SP1-mediated VEGFR2 expression. | Wang, W., et al. 2014. J Cell Physiol. 229: 1529-37. PMID: 24585635
- The atypical MAPK ERK3 potently suppresses melanoma cell growth and invasiveness. | Chen, M., et al. 2019. J Cell Physiol. 234: 13220-13232. PMID: 30569573
- ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis. | Bogucka, K., et al. 2021. Cancer Gene Ther. 28: 359-374. PMID: 33070159
- Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice. | Vallabhaneni, S., et al. 2022. Mol Oncol. 16: 1184-1199. PMID: 34719109
- Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth. | Jin, Y., et al. 2022. Oncogene. 41: 1752-1766. PMID: 35124697
- ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation. | Soulez, M., et al. 2022. J Cell Physiol. 237: 2271-2287. PMID: 35141958
- Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy. | Javary, J., et al. 2024. J Cell Physiol. 239: e30938. PMID: 36576983
- ERK3 Increases Snail Protein Stability by Inhibiting FBXO11-Mediated Snail Ubiquitination. | Kim, SH., et al. 2023. Cancers (Basel). 16: PMID: 38201533
- ERK3 is involved in regulating cardiac fibroblast function. | Sahadevan, P., et al. 2024. Physiol Rep. 12: e16108. PMID: 38872461
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERK 3 Antibody (E-3) | sc-374239 | 200 µg/ml | $316.00 | |||
ERK 3 Antibody (E-3): m-IgG Fc BP-HRP Bundle | sc-537940 | 200 µg Ab; 10 µg BP | $354.00 | |||
ERK 3 Antibody (E-3): m-IgGκ BP-HRP Bundle | sc-535425 | 200 µg Ab; 40 µg BP | $354.00 | |||
ERK 3 Antibody (E-3): m-IgG1 BP-HRP Bundle | sc-545460 | 200 µg Ab; 20 µg BP | $354.00 |