DDB1 Antibody (B-1): sc-137142
- DDB1 Antibody (B-1) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of DDB1 of human origin
- recommended for detection of DDB1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DDB1 Antibody (B-1) for WB applications. These reagents are now offered in bundles with DDB1 Antibody (B-1) (see ordering information below).
QUICK LINKS
DDB1 Antibody (B-1) is a mouse monoclonal IgG2a antibody that detects DDB1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDB1, a crucial component of the damaged DNA binding protein complex, plays a vital role in the cellular response to DNA damage, particularly in the repair of ultraviolet light-induced lesions. DDB1 is primarily located in the nucleus, where DDB1 participates in the nucleotide excision repair pathway, ensuring the integrity of the genome by recognizing and binding to damaged DNA, specifically cyclobutane pyrimidine dimers. DDB1′s nuclear localization enables timely repair of DNA lesions, thereby preventing mutations that could lead to skin cancer and other genetic disorders. Furthermore, mutations in DDB1 have been linked to xeroderma pigmentosum group E, a condition characterized by extreme sensitivity to sunlight and a predisposition to skin malignancies. Anti-DDB1 antibody (B-1) is an essential tool for researchers studying DNA repair mechanisms and the implications of DDB1 in various diseases, providing insights into the molecular underpinnings of genomic stability.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DDB1 Antibody (B-1) References:
- DDB1 Stimulates Viral Transcription of Hepatitis B Virus via HBx-Independent Mechanisms. | Kim, W., et al. 2016. J Virol. 90: 9644-9653. PMID: 27535046
- DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. | Tong, X., et al. 2017. Diabetes. 66: 2571-2582. PMID: 28790135
- DDB1 E3 ligase controls dietary fructose-induced ChREBPα stabilization and liver steatosis via CRY1. | Tong, X., et al. 2020. Metabolism. 107: 154222. PMID: 32246987
- Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. | Matyskiela, ME., et al. 2020. Nat Struct Mol Biol. 27: 319-322. PMID: 32251415
- DDB1 maintains intestinal homeostasis by preventing cell cycle arrest. | Zhao, L., et al. 2022. Cell Regen. 11: 18. PMID: 35641707
- Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy. | Teranishi, H., et al. 2022. Cell Rep. 40: 111349. PMID: 36103833
- Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4-Associated Factors, Cellular Functions, and Protein Substrates. | Raisch, J., et al. 2023. Mol Cell Proteomics. 22: 100644. PMID: 37689310
- Hepatocyte-specific loss of DDB1 attenuates hepatic steatosis but aggravates liver inflammation and fibrosis in MASH. | Gu, Q., et al. 2024. Hepatol Commun. 8: PMID: 38934719
- Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K. | Ghosh, P., et al. 2024. RSC Chem Biol. 6: 36-55. PMID: 39450271
- DDB1 prepares brown adipocytes for cold-induced thermogenesis. | Wang, X., et al. 2022. Life Metab. 1: 39-53. PMID: 39872690
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DDB1 Antibody (B-1) | sc-137142 | 200 µg/ml | $316.00 | |||
DDB1 Antibody (B-1): m-IgG Fc BP-HRP Bundle | sc-537409 | 200 µg Ab; 10 µg BP | $354.00 | |||
DDB1 Antibody (B-1): m-IgGκ BP-HRP Bundle | sc-534664 | 200 µg Ab; 40 µg BP | $354.00 | |||
DDB1 Antibody (B-1): m-IgG2a BP-HRP Bundle | sc-548008 | 200 µg Ab; 10 µg BP | $354.00 |