Date published: 2026-4-24

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DDB1 Inhibitors

DDB1 Inhibitors represent a diverse class of compounds designed to specifically target and inhibit the function of DDB1 (DNA damage-binding protein 1). These inhibitors act through various mechanisms, directly or indirectly influencing cellular processes and molecular interactions in which DDB1 plays a crucial role. Direct inhibitors such as DBeQ, MLN4924, RBX1 Inhibitor, HPH-15, ABBV-075, and MLN7243 directly disrupt the function of DDB1, leading to the inhibition of its cellular activities. These compounds interfere with the normal functioning of DDB1-containing complexes, affecting various pathways and molecular interactions where DDB1 is a key player. Indirect inhibitors, including Sirtinol, Nutlin-3, C646, MLN4924 analog, Spautin-1, and Piperlongumine, modulate pathways and interactions related to DDB1 indirectly. They influence proteins or processes associated with DDB1-containing complexes, resulting in altered cellular processes. Sirtinol, for instance, affects DDB1 through sirtuin modulation, while Nutlin-3 disrupts the interaction between DDB1 and MDM2 in the p53 pathway. The versatility of DDB1 Inhibitors offers researchers valuable tools to dissect the intricate functions of DDB1 and its involvement in cellular processes and molecular pathways.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

DBeQ

177355-84-9sc-499943
10 mg
$330.00
1
(0)

DBeQ is a chemical compound known to be a direct inhibitor of DDB1. By specifically targeting DDB1, DBeQ disrupts its function and inhibits its cellular activities. This direct inhibition leads to altered cellular processes dependent on DDB1, influencing various pathways and molecular interactions in which DDB1 is involved.

MLN 4924

905579-51-3sc-484814
1 mg
$286.00
1
(0)

MLN4924 is a chemical compound that acts as a direct inhibitor of DDB1 by disrupting its function. This compound specifically inhibits the neddylation of cullin-RING ligases (CRLs), including DDB1-containing CRLs.

MLN7243

1450833-55-2sc-507338
5 mg
$340.00
(0)

MLN7243 is a chemical compound that acts as a direct inhibitor of DDB1. By specifically targeting DDB1, MLN7243 disrupts its function and inhibits its cellular activities. This direct inhibition leads to altered cellular processes dependent on DDB1, influencing various pathways and molecular interactions in which DDB1 is involved.

Sirtinol

410536-97-9sc-205976
sc-205976A
1 mg
5 mg
$38.00
$113.00
14
(1)

Sirtinol is a chemical compound that indirectly inhibits DDB1 by modulating the activity of sirtuins. As sirtuins are known to interact with DDB1-containing complexes, Sirtinol indirectly affects the function of DDB1 by influencing these interactions. This indirect inhibition leads to altered cellular processes dependent on DDB1, influencing various pathways and molecular interactions in which DDB1 is involved.

(–)-Nutlin-3

675576-98-4sc-222086
sc-222086A
1 mg
5 mg
$122.00
$219.00
2
(1)

Nutlin-3 is a chemical compound that indirectly inhibits DDB1 by disrupting the interaction between DDB1 and MDM2. As MDM2 is a key regulator of the p53 pathway and interacts with DDB1, Nutlin-3 indirectly influences DDB1-mediated cellular processes. This indirect inhibition leads to altered pathways and molecular interactions in which DDB1 is involved.

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$265.00
$944.00
5
(1)

C646 is a chemical compound that indirectly inhibits DDB1 by targeting the acetyltransferase activity of p300, a protein that interacts with DDB1. Through this indirect inhibition, C646 influences the acetylation status of proteins involved in DDB1-containing complexes, leading to altered cellular processes and molecular interactions in which DDB1 is involved.

Spautin-1

1262888-28-7sc-507306
10 mg
$168.00
(0)

Spautin-1 is a chemical compound that indirectly inhibits DDB1 by promoting the degradation of Vps34, a protein that interacts with DDB1. Through this indirect inhibition, Spautin-1 influences the stability of DDB1-containing complexes, leading to altered cellular processes and molecular interactions in which DDB1 is involved.

Piperlongumine

20069-09-4sc-364128
10 mg
$107.00
(1)

Piperlongumine is a chemical compound that indirectly inhibits DDB1 by modulating the activity of the Nrf2 pathway. As Nrf2 interacts with DDB1, Piperlongumine indirectly affects the function of DDB1 by influencing these interactions. This indirect inhibition leads to altered cellular processes dependent on DDB1, influencing various pathways and molecular interactions in which DDB1 is involved.