COL5A1 Antibody (B-11): sc-166194

COL5A1 Antibody (B-11) is a mouse monoclonal IgG2b antibody that detects COL5A1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COL5A1, a member of the collagen family, plays a crucial role in the formation of type V collagen, which is essential for the structural integrity of various tissues, including skin, tendons, and blood vessels. COL5A1 is primarily located in the extracellular matrix, where COL5A1 contributes to the assembly of collagen fibrils and regulates the diameter of these fibrils, ensuring proper tissue architecture and mechanical properties. COL5A1′s location in the extracellular matrix not only provides tensile strength but also influences cellular behaviors such as migration and differentiation, which are vital for wound healing and tissue repair. COL5A1 interacts with other collagen types and extracellular matrix components, further underscoring COL5A1′s significance in maintaining the overall functionality and stability of connective tissues. With versatile applications and a critical role in connective tissue biology, anti-COL5A1 antibody (B-11) serves as an invaluable tool for researchers studying collagen-related disorders and tissue engineering.

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COL5A1 Antibody (B-11) References:

1. The COL5A1 gene, ultra-marathon running performance, and range of motion.  |  Brown, JC., et al. 2011. Int J Sports Physiol Perform. 6: 485-96. PMID: 21934170
2. The COL5A1 gene is associated with increased risk of carpal tunnel syndrome.  |  Burger, M., et al. 2015. Clin Rheumatol. 34: 767-74. PMID: 24966028
3. Overexpression of COL5A1 promotes tumor progression and metastasis and correlates with poor survival of patients with clear cell renal cell carcinoma.  |  Feng, G., et al. 2019. Cancer Manag Res. 11: 1263-1274. PMID: 30799953
4. LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging miR-1277-5p and upregulating COL5A1.  |  Wei, Z., et al. 2020. Gastric Cancer. 23: 1018-1032. PMID: 32583079
5. A Novel Recurrent COL5A1 Genetic Variant Is Associated With a Dysplasia-Associated Arterial Disease Exhibiting Dissections and Fibromuscular Dysplasia.  |  Richer, J., et al. 2020. Arterioscler Thromb Vasc Biol. 40: 2686-2699. PMID: 32938213
6. Molecular alterations due to Col5a1 haploinsufficiency in a mouse model of classic Ehlers-Danlos syndrome.  |  Machol, K., et al. 2022. Hum Mol Genet. 31: 1325-1335. PMID: 34740257
7. COL5A1 Promotes the Progression of Gastric Cancer by Acting as a ceRNA of miR-137-3p to Upregulate FSTL1 Expression.  |  Yang, M., et al. 2022. Cancers (Basel). 14: PMID: 35805015
8. β2-Microglobulin Elevates COL5A1 mRNA in the Subsynovial Connective Tissue of Patients Receiving Hemodialysis With Carpal Tunnel Syndrome.  |  Muneshige, K., et al. 2022. Cureus. 14: e32423. PMID: 36514703
9. Activated PARP1/FAK/COL5A1 signaling facilitates the tumorigenesis of cholesterol-resistant ovarian cancer cells through promoting EMT.  |  He, Z., et al. 2024. Cell Signal. 124: 111419. PMID: 39293744
10. COL5A1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome type II.  |  Greenspan, DS., et al. 1995. Genomics. 25: 737-9. PMID: 7759113

The preferred COL5A1 antibody is COL5A1 Antibody (C-5): sc-166155.