caspase-9 Antibody (4i31): sc-70507

caspase-9 Antibody (4i31) is a mouse monoclonal IgG1 antibody that detects caspase-9 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Caspase-9 plays a pivotal role in the intrinsic pathway of apoptosis, acting as an initiator caspase that is crucial for the activation of downstream effector caspases, such as caspase-3 and caspase-7. This activation is essential for the execution of programmed cell death, a process vital for maintaining cellular homeostasis and eliminating damaged or unwanted cells. Proper functioning of caspase-9 is particularly important in cancer, where dysregulation of apoptosis can lead to tumorigenesis and resistance to therapy. Caspase-9 is located in the cytosol and activates in response to apoptotic signals, such as mitochondrial outer membrane permeabilization, highlighting its role as a key regulator in cellular response to stress and damage. The ability of caspase-9 to cleave and activate other caspases underscores its importance in the apoptotic cascade, making caspase-9 a critical target for research in cancer biology and therapeutic development.

The preferred caspase-9 antibody is caspase-9 Antibody (96.1.23): sc-56076.