caspase-8 p18 Antibody (D-7): sc-393776
- caspase-8 p18 Antibody (D-7) is a mouse monoclonal IgG2a, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 345-374 at the C-terminus of caspase-8 p18 of human origin
- recommended for detection of p18 subunit and precursor of caspase-8 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See caspase-8 (8CSP03): sc-56070 for caspase-8 p18 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for caspase-8 p18 Antibody (D-7) for WB and IHC(P) applications. These reagents are now offered in bundles with caspase-8 p18 Antibody (D-7) (see ordering information below).
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Caspase-8 p18 Antibody (D-7) is a mouse monoclonal IgG2a antibody that detects caspase-8 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Caspase-8 plays a crucial role in the apoptotic signaling pathway, acting as an initiator caspase that activates downstream effector caspases, thereby regulating programmed cell death. Caspase-8 is primarily located in the cytoplasm and is essential for the formation of the death-inducing signaling complex (DISC) when binding to the adaptor molecule FADD. Proper localization of caspase-8 ensures efficient activation in response to apoptotic signals, particularly those mediated by tumor necrosis factor receptors. Dysregulation of caspase-8 can lead to severe consequences, including immune deficiencies and increased susceptibility to various diseases, highlighting caspase-8′s importance in maintaining cellular homeostasis and immune responses. Anti-caspase-8 antibody (D-7) serves as an invaluable tool for researchers studying apoptosis and related pathways, providing insights into the mechanisms of cell death and potential therapeutic targets for diseases associated with caspase dysfunction.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-8 p18 Antibody (D-7) | sc-393776 | 200 µg/ml | $322.00 | |||
caspase-8 p18 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-540910 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-8 p18 Antibody (D-7): m-IgG2a BP-HRP Bundle | sc-546974 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-8 p18 (D-7) Neutralizing Peptide | sc-393776 P | 100 µg/0.5 ml | $69.00 |