caspase-8 Antibody (FLICE4-1-20): sc-56072

Caspase-8 Antibody (FLICE4-1-20) is a mouse monoclonal IgG1 antibody that detects caspase-8 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Caspase-8 plays a crucial role in the apoptotic signaling pathway, acting as an initiator caspase that activates downstream effector caspases, thereby orchestrating the process of programmed cell death. Caspase-8 is primarily located in the cytoplasm and is essential for the formation of the death-inducing signaling complex (DISC) when binding to the adaptor molecule FADD. Proper functioning of caspase-8 is vital for maintaining cellular homeostasis and immune responses, as activation leads to the execution of apoptosis in response to various stimuli, including those from tumor necrosis factor receptors. Dysregulation or defects in the CASP8 gene can result in caspase-8 deficiency disorder (CASP8D), which is associated with severe immunodeficiency and splenomegaly due to impaired activation of T lymphocytes, natural killer cells, and B lymphocytes. Anti-caspase-8 antibody (FLICE4-1-20) is an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer and autoimmune disorders.

The preferred caspase-8 p18 antibody is caspase-8 p18 Antibody (D-8): sc-5263.