caspase-6 Antibody (7.1.65): sc-73539

Caspase-6 Antibody (7.1.65) is a mouse monoclonal IgG1 antibody that detects caspase-6 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Caspase-6 is a crucial member of the Ced-3/caspase family of cysteine proteases, which play a vital role in the apoptotic process by cleaving specific target proteins essential for cellular longevity and integrity. Notably, caspase-6 is involved in the cleavage of nuclear lamins, which are integral to maintaining the structural integrity of the nuclear envelope and overall cellular morphology. This function is particularly important as it ensures proper cell division and prevents genomic instability, which can lead to various diseases, including cancer. The ability of caspase-6 to modulate the apoptotic pathway highlights its significance in regulating cell death and survival, making caspase-6 a critical target for research in apoptosis and related therapeutic interventions. Anti-caspase-6 antibody (7.1.65) is therefore an invaluable tool for scientists studying the mechanisms of apoptosis and the role of caspases in human health and disease.

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caspase-6 Antibody (7.1.65) References:

1. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.  |  Flygare, JA. and Arkin, MR. 2014. Curr Top Med Chem. 14: 319-25. PMID: 24283214
2. Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.  |  LeBlanc, AC., et al. 2014. Cell Death Differ. 21: 696-706. PMID: 24413155
3. Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.  |  Yao, Y., et al. 2016. J Biol Chem. 291: 17450-66. PMID: 27325699
4. Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.  |  Bartel, A., et al. 2017. PLoS One. 12: e0180203. PMID: 28686630
5. Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.  |  Dagbay, KB., et al. 2017. Biochemistry. 56: 4568-4577. PMID: 28726391
6. Identification of Allosteric Inhibitors against Active Caspase-6.  |  Tubeleviciute-Aydin, A., et al. 2019. Sci Rep. 9: 5504. PMID: 30940883
7. Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense.  |  Zheng, M. and Kanneganti, TD. 2020. J Cell Immunol. 2: 341-347. PMID: 33426542
8. The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner.  |  Valionyte, E., et al. 2022. Cell Death Differ. 29: 1211-1227. PMID: 34862482
9. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications.  |  Theofilas, P., et al. 2022. Neuropathol Appl Neurobiol. 48: e12819. PMID: 35508761
10. Role of cited-1 and caspase-6 expression in HELLP syndrome.  |  Öcal, E., et al. 2023. Eur Rev Med Pharmacol Sci. 27: 3082-3087. PMID: 37070911

The preferred caspase-6 p10 antibody is caspase-6 p10 Antibody (H-12): sc-377393.