caspase-6 Antibody (6CSP01): sc-56061
- caspase-6 Antibody (6CSP01) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against the prodomain of caspase-6 of human origin
- recommended for detection of caspase-6 of human origin by WB and IP
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-6 Antibody (6CSP01) for WB applications. These reagents are now offered in bundles with caspase-6 Antibody (6CSP01) (see ordering information below).
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caspase-6 Antibody (6CSP01) is a mouse monoclonal IgG1 antibody that detects caspase-6 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Caspase-6 is a crucial member of the Ced-3/caspase-1 family of cysteine proteases, which are integral to the apoptotic process, playing a significant role in programmed cell death. anti-caspase-6 antibody (6CSP01) targets a protein primarily located in the cytoplasm that is activated in response to apoptotic signals, where caspase-6 cleaves specific substrates to facilitate cellular disassembly. Notably, caspase-6 is known to cleave nuclear lamins, which are essential for maintaining the structural integrity of the nuclear envelope and overall cellular morphology. The proper functioning of caspase-6 is vital, as dysregulation can lead to various pathological conditions, including neurodegenerative diseases and cancer. caspase-6 (6CSP01) monoclonal antibody enables researchers to gain insights into the mechanisms of apoptosis and the role of caspase-6 in cellular health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
caspase-6 Antibody (6CSP01) References:
- Activation and regulation of caspase-6 and its role in neurodegenerative diseases. | Wang, XJ., et al. 2015. Annu Rev Pharmacol Toxicol. 55: 553-72. PMID: 25340928
- Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke. | Shabanzadeh, AP., et al. 2015. Cell Death Dis. 6: e1967. PMID: 26539914
- Caspase 6 has a protective role in SOD1(G93A) transgenic mice. | Hogg, MC., et al. 2016. Biochim Biophys Acta. 1862: 1063-73. PMID: 26976329
- Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding. | Dagbay, KB., et al. 2017. J Biol Chem. 292: 4885-4897. PMID: 28154009
- Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain. | Berta, T., et al. 2017. Mediators Inflamm. 2017: 9383184. PMID: 28270702
- Differential involvement of caspase-6 in amyloid-β-induced fragmentation of lamin A and B. | Islam, MI., et al. 2020. Biochem Biophys Rep. 24: 100839. PMID: 33145443
- Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections. | Zheng, M., et al. 2021. J Biol Chem. 297: 101379. PMID: 34740613
- Proviral role of caspase-6 in coronavirus infections. | Wong, LR. and Perlman, S. 2023. Cell Res. 33: 7-8. PMID: 36131099
- Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation. | Lin, Y., et al. 2023. Cell Commun Signal. 21: 282. PMID: 37828624
- Knocking down macrophages Caspase-6 through HMGB1 coordinates macrophage trophoblast crosstalk to suppress ferroptosis and alleviate preeclampsia. | Deng, Y., et al. 2024. Int Immunopharmacol. 140: 112859. PMID: 39121610
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-6 Antibody (6CSP01) | sc-56061 | 200 µg/ml | $322.00 | |||
caspase-6 Antibody (6CSP01): m-IgG Fc BP-HRP Bundle | sc-537093 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-6 Antibody (6CSP01): m-IgGκ BP-HRP Bundle | sc-534281 | 200 µg Ab; 40 µg BP | $361.00 | |||
caspase-6 Antibody (6CSP01): m-IgG1 BP-HRP Bundle | sc-544998 | 200 µg Ab; 20 µg BP | $361.00 |