caspase-6 Antibody (12.1.91): sc-81652

Caspase-6 Antibody (12.1.91) is a mouse monoclonal IgG1 antibody that detects caspase-6 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Caspase-6 is a crucial member of the Ced-3/caspase family of cysteine proteases, which play a vital role in the apoptotic process by cleaving specific target proteins essential for cellular longevity and integrity. Notably, caspase-6 is involved in the cleavage of nuclear lamins, which are integral to maintaining the structural integrity of the nuclear envelope and overall cellular morphology. This function is particularly important as it ensures proper cell division and prevents genomic instability, which can lead to various diseases, including cancer. The ability of caspase-6 to modulate the apoptotic pathway highlights its significance in both normal physiological processes and pathological conditions. Anti-caspase-6 antibody (12.1.91) is an invaluable tool for researchers studying apoptosis and related cellular mechanisms.

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caspase-6 Antibody (12.1.91) References:

1. Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis.  |  Allsopp, TE., et al. 2000. Cell Death Differ. 7: 984-93. PMID: 11279545
2. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells.  |  Monnier, PP., et al. 2011. J Neurosci. 31: 10494-505. PMID: 21775595
3. Caspase-6 as a novel early target in the treatment of Alzheimer's disease.  |  LeBlanc, AC. 2013. Eur J Neurosci. 37: 2005-18. PMID: 23773070
4. Expression and activation of caspase-6 in human fetal and adult tissues.  |  Godefroy, N., et al. 2013. PLoS One. 8: e79313. PMID: 24265764
5. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.  |  Dagbay, KB. and Hardy, JA. 2017. Proc Natl Acad Sci U S A. 114: E7977-E7986. PMID: 28864531
6. Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.  |  Noël, A., et al. 2018. Cell Death Differ. 25: 1319-1335. PMID: 29352267
7. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.  |  MacPherson, DJ., et al. 2019. J Biol Chem. 294: 71-88. PMID: 30420425
8. Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers.  |  Capo-Chichi, CD., et al. 2018. Biomark Res. 6: 30. PMID: 30450209
9. Compromised IGF signaling causes caspase-6 activation in Huntington disease.  |  Skotte, NH., et al. 2020. Exp Neurol. 332: 113396. PMID: 32622701
10. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits.  |  Noël, A., et al. 2021. Cell Death Dis. 12: 227. PMID: 33649324

The preferred caspase-6 p10 antibody is caspase-6 p10 Antibody (H-12): sc-377393.