caspase-10 p10 Antibody (E-11): sc-393983

Caspase-10 p10 Antibody (E-11) is a mouse monoclonal IgM antibody that detects the caspase-10 p10 subunit and precursor of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-caspase-10 p10 antibody (E-11) is available in a non-conjugated form, providing flexibility for various experimental needs. Caspase-10 is a crucial member of the Ced-3/caspase-1 family of cysteine proteases, which are integral to the apoptotic process, facilitating programmed cell death by cleaving specific target proteins essential for cellular longevity. Caspase-10 is primarily located in the cytosol and is activated in response to apoptotic signals, where caspase-10 plays a pivotal role in the activation of downstream effector caspases, such as caspase-3 and caspase-7. Proper functioning of caspase-10 is vital for maintaining cellular homeostasis, as dysregulation of caspase-10 activity can lead to various diseases, including cancer and neurodegenerative disorders. Caspase-10 p10 monoclonal antibody (E-11) enables researchers to gain insights into the mechanisms of apoptosis and the role of caspases in disease progression, making caspase-10 p10 monoclonal antibody (E-11) an invaluable tool for understanding cellular responses to stress and damage.

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caspase-10 p10 Antibody (E-11) References:

1. Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.  |  Sprick, MR., et al. 2002. EMBO J. 21: 4520-30. PMID: 12198154
2. Caspase-activation pathways in apoptosis and immunity.  |  Creagh, EM., et al. 2003. Immunol Rev. 193: 10-21. PMID: 12752666
3. In vitro and in vivo antitumor activity of the novel derivatized polyvinyl alcohol-based polymer P10(4).  |  Raffaghello, L., et al. 2006. Clin Cancer Res. 12: 3485-93. PMID: 16740774
4. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis.  |  Chen, H., et al. 2009. Mol Cell Biol. 29: 3657-64. PMID: 19380486
5. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.  |  Lindahl, T., et al. 1995. Trends Biochem Sci. 20: 405-11. PMID: 8533153
6. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.  |  Duan, H., et al. 1996. J Biol Chem. 271: 1621-5. PMID: 8576161
7. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.  |  Casciola-Rosen, L., et al. 1996. J Exp Med. 183: 1957-64. PMID: 8642305
8. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.  |  Duan, H., et al. 1996. J Biol Chem. 271: 16720-4. PMID: 8663294
9. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.  |  Takahashi, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 8395-400. PMID: 8710882
10. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.  |  Fernandes-Alnemri, T., et al. 1996. Proc Natl Acad Sci U S A. 93: 7464-9. PMID: 8755496
11. The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex.  |  Simbulan-Rosenthal, CM., et al. 1996. Biochemistry. 35: 11622-33. PMID: 8794742
12. Caspases: the executioners of apoptosis.  |  Cohen, GM. 1997. Biochem J. 326 (Pt 1): 1-16. PMID: 9337844

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caspase-10 p10 Antibody (E-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-caspase-10 p10 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caspase-10 p10 Antibody (E-11) Specifications

Alternate Product Name: caspase-10 p10

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 458-479

Epitope Target: caspase-10 p10

Epitope Species: human

Product Reactivity/Detection: caspase-10 p10 subunit and precursor

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for caspase-10 p10 Antibody (E-11): P: Blocking Peptide

The preferred caspase-10 antibody is caspase-10 Antibody (WW-H4): sc-134299.