Date published: 2026-4-29

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caspase-10 Substrates

Santa Cruz Biotechnology now offers a broad range of caspase-10 Substrates for use in various applications. Caspase-10 substrates are essential tools for studying the mechanisms of apoptosis, particularly in the context of the extrinsic pathway of cell death, which is initiated by external signals such as death ligands binding to their receptors. Caspase-10, a member of the caspase family of cysteine proteases, plays a crucial role in the early stages of this pathway by cleaving specific substrates that propagate the apoptotic signal within the cell. By using caspase-10 substrates, researchers can accurately measure and monitor the activity of this enzyme, providing insights into its role in mediating apoptosis. These substrates are widely used in assays to explore how caspase-10 interacts with other proteins and contributes to the cascade of events leading to cell death. Additionally, caspase-10 substrates are valuable in high-throughput screening assays aimed at identifying novel modulators of caspase-10 activity, which can further elucidate the regulatory networks involved in apoptosis. The ability to study caspase-10 activity in real-time using specific substrates allows scientists to investigate the precise molecular mechanisms underlying apoptotic processes and to understand how alterations in caspase-10 function might contribute to various biological outcomes. These substrates are crucial for advancing research in cell biology, immunology, and related fields, providing a deeper understanding of how cells regulate life and death decisions. View detailed information on our available caspase-10 Substrates by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ac-DEVD-AFC

201608-14-2sc-311274
sc-311274A
1 mg
5 mg
$65.00
$200.00
13
(1)

Ac-DEVD-AFC is a fluorogenic substrate specifically designed for caspase-10, featuring a unique structure that facilitates selective recognition by the enzyme. The incorporation of the AFC (7-amino-4-trifluoromethylcoumarin) moiety allows for enhanced fluorescence upon cleavage, enabling real-time monitoring of caspase activity. Its design promotes rapid reaction kinetics, making it an effective tool for investigating apoptotic pathways and cellular signaling mechanisms associated with caspase-10 activation.

Ac-DEVD-pNA

189950-66-1sc-311275
sc-311275A
sc-311275B
sc-311275C
1 mg
5 mg
25 mg
250 mg
$97.00
$286.00
$734.00
$4692.00
14
(1)

Ac-DEVD-pNA is a synthetic substrate tailored for caspase-10, characterized by its p-nitroaniline (pNA) group, which provides a distinct chromogenic response upon enzymatic cleavage. This substrate exhibits high specificity for caspase-10, allowing for precise detection of its activity. The reaction kinetics are optimized for rapid turnover, facilitating detailed studies of apoptotic signaling pathways. Its unique molecular interactions enhance the understanding of caspase-10's role in cellular processes.

Ac-IETD-AFC

211990-57-7sc-311276
sc-311276A
5 mg
10 mg
$281.00
$453.00
1
(1)

Ac-IETD-AFC is a synthetic substrate designed for caspase-10, featuring a 7-amino-4-trifluoromethylcoumarin (AFC) moiety that emits fluorescence upon cleavage. This substrate is notable for its selective recognition of caspase-10, enabling sensitive monitoring of its enzymatic activity. The reaction kinetics are finely tuned, promoting efficient substrate turnover, which aids in elucidating the intricate mechanisms of apoptosis and cellular regulation. Its distinct molecular interactions provide insights into caspase-10's functional dynamics.

Z-DEVD-AFC

sc-296746
sc-296746A
5 mg
50 mg
$151.00
$1358.00
1
(0)

Z-DEVD-AFC is a specialized substrate tailored for caspase-10, characterized by its unique fluorogenic properties. Upon enzymatic cleavage, it releases a fluorescent signal, allowing for precise detection of caspase-10 activity. The substrate's design enhances its affinity for the active site of caspase-10, facilitating rapid reaction kinetics. This specificity aids in dissecting apoptotic pathways and understanding the regulatory mechanisms of cell death, highlighting its role in cellular signaling.