caspase-10 Antibody (WW-H4): sc-134299

Caspase-10 Antibody (WW-H4) is a mouse monoclonal IgG2a kappa light chain antibody that detects human caspase-10 protein by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-caspase-10 antibody (WW-H4) is available as a non-conjugated format. Caspase-10 is a crucial member of the caspase family, which consists of cysteine proteases that play a vital role in the apoptotic process. Caspase-10 is primarily located in the cytosol and is essential for initiating apoptosis by activating downstream effector caspases such as caspase-3 and caspase-7 in response to apoptotic signals. Proper functioning of caspase-10 is critical for maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which can lead to various diseases, including cancer. Dysregulation of caspase-10 activity has been implicated in several pathological conditions, highlighting caspase-10′s importance as a potential therapeutic target. Caspase-10′s ability to interact with other proteins in the apoptotic pathway further underscores its significance in cellular signaling and programmed cell death execution.

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caspase-10 Antibody (WW-H4) References:

1. Caspase-10 is an initiator caspase in death receptor signaling.  |  Wang, J., et al. 2001. Proc Natl Acad Sci U S A. 98: 13884-8. PMID: 11717445
2. Taxol induces caspase-10-dependent apoptosis.  |  Park, SJ., et al. 2004. J Biol Chem. 279: 51057-67. PMID: 15452117
3. Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer.  |  Xu, B., et al. 2008. Oncology. 74: 229-36. PMID: 18716417
4. Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis.  |  Kumari, R., et al. 2019. Nat Commun. 10: 4255. PMID: 31534141
5. Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death.  |  Cho, M., et al. 2022. J Autoimmun. 133: 102940. PMID: 36323068
6. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.  |  Lindahl, T., et al. 1995. Trends Biochem Sci. 20: 405-11. PMID: 8533153
7. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.  |  Duan, H., et al. 1996. J Biol Chem. 271: 1621-5. PMID: 8576161
8. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.  |  Casciola-Rosen, L., et al. 1996. J Exp Med. 183: 1957-64. PMID: 8642305
9. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.  |  Duan, H., et al. 1996. J Biol Chem. 271: 16720-4. PMID: 8663294
10. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.  |  Takahashi, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 8395-400. PMID: 8710882
11. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.  |  Fernandes-Alnemri, T., et al. 1996. Proc Natl Acad Sci U S A. 93: 7464-9. PMID: 8755496
12. The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex.  |  Simbulan-Rosenthal, CM., et al. 1996. Biochemistry. 35: 11622-33. PMID: 8794742

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caspase-10 Antibody (WW-H4) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-caspase-10 Antibody (WW-H4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caspase-10 Antibody (WW-H4) Specifications

Alternate Product Name: caspase-10

Product Clone Name: WW-H4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-111

Epitope Target: caspase-10

Epitope Species: human

Product Reactivity/Detection: caspase-10 precursor

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for caspase-10 Antibody (WW-H4): N/A

The preferred caspase-10 p10 antibody is caspase-10 p10 Antibody (E-11): sc-393983.