CYP2C19 Activators
CYP2C19 Activators comprise a class of compounds known to enhance the functional activity of the CYP2C19 enzyme. These compounds specifically interact with CYP2C19, augmenting its enzymatic activity by promoting substrate binding and turnover or by stabilizing the enzyme and increasing its substrate affinity. For instance, quercetin and apigenin enhance CYP2C19's ability to catalyze reactions involving its substrates by promoting substrate binding and turnover.
Similarly, indole-3-carbinol, resveratrol, and genistein enhance CYP2C19's activity by stabilizing its structure and improving its capacity to bind and metabolize substrates. Other compounds like sulforaphane, curcumin, capsaicin, diallyl sulfide, ellagic acid, and silymarin enhance CYP2C19's activity by binding to the enzyme and promoting substrate binding and metabolism. These interactions contribute to the understanding of CYP2C19's role in various metabolic processes, including drug metabolism and the bioactivation of carcinogens. By elucidating the mechanisms of action for these activators, we gain crucial insights into how these compounds may be employed to enhance drug metabolism or mitigate toxicological risks associated with certain chemicals.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, can enhance the activity of CYP2C19 by binding to the enzyme and promoting substrate binding and metabolism. This interaction leads to increased enzymatic activity and improved catalytic efficiency of CYP2C19. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol, found in cruciferous vegetables, stabilizes the structure of CYP2C19 and improves its capacity to bind and metabolize substrates, thereby enhancing its enzymatic activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can increase the functional activity of CYP2C19 by binding to the enzyme and promoting substrate binding and metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol enhances the activity of CYP2C19 by promoting the enzyme's stability and substrate affinity, leading to increased catalytic efficiency. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin can enhance the activity of CYP2C19 by binding to the enzyme and promoting substrate binding and metabolism. | ||||||
Diallyl sulfide | 592-88-1 | sc-204718 sc-204718A | 25 g 100 g | $42.00 $106.00 | 3 | |
Diallyl sulfide enhances the functional activity of CYP2C19 by promoting substrate binding and turnover, leading to improved catalytic efficiency. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid can increase the functional activity of CYP2C19 by binding to the enzyme and promoting substrate binding and metabolism. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a soy isoflavone, enhances the functional activity of CYP2C19 by promoting the enzyme's stability and substrate affinity. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin, a plant flavonoid, increases the CYP2C19's ability to catalyze reactions involving its substrates by promoting substrate binding and turnover. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Silymarin, a compound found in milk thistle, enhances the functional activity of CYP2C19 by promoting the enzyme's stability and substrate affinity. | ||||||