beta-catenin Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 functions as a potent inhibitor of the Wnt signaling pathway by disrupting the interaction between beta-catenin and its transcriptional co-activators. This compound selectively binds to the protein's armadillo repeats, preventing its nuclear translocation. Its unique structural features enhance its affinity for the target, modulating downstream gene expression. Additionally, IWP-2 exhibits rapid kinetics in cellular assays, showcasing its effectiveness in altering pathway dynamics. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 acts as a selective inhibitor of β-catenin/Tcf interactions, effectively blocking the transcriptional activity associated with the Wnt signaling pathway. By targeting the β-catenin's binding domain, it disrupts the formation of the β-catenin/Tcf complex, leading to altered gene regulation. Its unique molecular structure allows for specific interactions that stabilize the inactive conformation of β-catenin, influencing cellular signaling dynamics and pathway modulation. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo is a potent modulator of β-catenin activity, specifically designed to disrupt its interaction with the Tcf transcription factors. By stabilizing the phosphorylated form of β-catenin, it promotes its degradation via the proteasome pathway. This selective action alters the balance of Wnt signaling, influencing downstream gene expression. Its unique binding affinity and conformational changes in β-catenin provide a nuanced approach to regulating cellular signaling networks. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $131.00 $495.00 | 7 | |
PNU-74654 acts as a selective inhibitor of β-catenin, targeting its interaction with transcriptional co-activators. This compound enhances the phosphorylation of β-catenin, facilitating its recognition by the E3 ubiquitin ligase complex, which leads to increased proteasomal degradation. Its distinct molecular interactions and kinetic profile allow for precise modulation of Wnt signaling pathways, ultimately influencing cellular processes through altered gene regulatory mechanisms. | ||||||
iCRT 14 | 677331-12-3 | sc-362746 sc-362746A | 10 mg 50 mg | $189.00 $771.00 | 9 | |
iCRT 14 functions as a potent modulator of β-catenin by disrupting its binding to TCF/LEF transcription factors. This compound promotes the phosphorylation of β-catenin, enhancing its turnover and reducing its nuclear accumulation. Its unique ability to interfere with the β-catenin/TCF complex alters downstream gene expression, impacting cellular signaling cascades. The compound's specific interactions and kinetics provide a nuanced approach to regulating Wnt pathway dynamics. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $180.00 $651.00 | ||
PKF118-310 acts as a selective inhibitor of β-catenin, primarily by stabilizing its interactions with the destruction complex, thereby promoting its degradation. This compound uniquely alters the conformational dynamics of β-catenin, influencing its affinity for various binding partners. By modulating the protein's stability and localization, PKF118-310 effectively disrupts the Wnt signaling pathway, leading to significant changes in cellular behavior and gene regulation. | ||||||
IWR-1-exo | 1127442-87-8 | sc-295216 sc-295216A | 5 mg 10 mg | $77.00 $121.00 | 2 | |
IWR-1-exo functions as a potent modulator of β-catenin by promoting its interaction with the axin complex, facilitating the recruitment of β-catenin for proteasomal degradation. This compound uniquely enhances the phosphorylation of β-catenin, altering its stability and cellular distribution. By influencing the dynamics of the Wnt signaling cascade, IWR-1-exo effectively shifts the balance of cellular signaling, impacting gene expression and cellular fate decisions. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW 55 acts as a selective inhibitor of β-catenin, disrupting its interaction with TCF/LEF transcription factors. This compound uniquely stabilizes the axin-β-catenin complex, promoting β-catenin's ubiquitination and subsequent degradation. By modulating the Wnt signaling pathway, JW 55 alters the kinetics of β-catenin accumulation in the nucleus, thereby influencing downstream target gene activation and cellular responses to environmental cues. | ||||||
TAK 715 | 303162-79-0 | sc-362799 sc-362799A | 10 mg 50 mg | $185.00 $781.00 | ||
TAK 715 functions as a potent modulator of β-catenin activity, specifically targeting its binding dynamics with transcriptional co-activators. This compound enhances the phosphorylation of β-catenin, facilitating its recognition by the proteasome for degradation. By influencing the stability of the β-catenin destruction complex, TAK 715 alters the balance of cellular signaling pathways, leading to distinct regulatory effects on gene expression and cellular behavior. | ||||||