TAK 715 CAS: 303162-79-0
MF: C24H21N3OS
MW: 399.51
An inhibitor of p38, Wnt/β-catenin , and CK1δ/ε.

TAK 715 (CAS 303162-79-0)

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Application: An inhibitor of p38, Wnt/β-catenin , and CK1δ/ε
CAS Number: 303162-79-0
Purity: ≤99%
Molecular Weight: 399.51
Molecular Formula: C24H21N3OS
* Refer to Certificate of Analysis for lot specific data (including water content).

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK1δ/ε.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (50 mM).
Storage :
Store at 4° C
Melting Point :
271.62° C (Predicted)
Boiling Point :
491.04° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
p38 MAPKα: IC50 = 7.1 nM (human); THP-1 (Acute monocytic leukemia cells): IC50 = 48 nM (human); MAP kinase p38 beta: IC50 = 200 nM (human); c-Jun N-terminal kinase 1: IC50 = >10 µM (human)
pK Values :
pKa: 11.88 (Predicted), pKb: 2.9 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9952773
MDL Number :
MFCD17012805
Beilstein Registry :
10291030
SMILES :
CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C

Download SDS (MSDS)

Certificate of Analysis

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