ZFP873 Activators
Zfp873, a zinc finger protein, plays a crucial role in transcriptional regulation by RNA polymerase II, exerting its DNA-binding transcription factor activity. This nuclear-localized protein is predicted to interact with specific cis-regulatory regions, contributing to the fine-tuning of gene expression. Activation of Zfp873 involves a complex interplay of chemical modulators targeting various cellular pathways. Trichostatin A, a histone deacetylase (HDAC) inhibitor, indirectly activates Zfp873 by promoting histone acetylation and modifying the chromatin landscape, facilitating its binding to cis-regulatory regions. Curcumin, a natural polyphenol, influences Zfp873 through its anti-inflammatory properties and epigenetic modulation, promoting enhanced transcriptional regulation. JQ1, an inhibitor of bromodomain-containing proteins, indirectly activates Zfp873 by altering chromatin structure and facilitating RNA polymerase II-mediated transcription. These chemicals exemplify how epigenetic modulation and chromatin accessibility contribute to Zfp873 activation.
Additional compounds like 5-Azacytidine, Sodium Butyrate, A-485, Resveratrol, SAHA, Betulinic Acid, Decitabine, Vorinostat, and DZNep act as indirect activators by targeting DNA methylation, histone acetylation, and methylation processes. Their influence on the epigenetic landscape enhances Zfp873's binding to cis-regulatory regions, promoting its transcriptional regulatory function in the nucleus. This comprehensive understanding of Zfp873 activation sheds light on the intricate mechanisms governing its role in transcriptional regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor impacting epigenetic regulation. Potential indirect activator of Zfp873 by inhibiting HDACs, leading to histone acetylation and altered chromatin structure in cis-regulatory regions. Trichostatin A's role involves epigenetic modifications that enhance Zfp873 binding to DNA, promoting transcriptional regulation by RNA polymerase II. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural polyphenol affecting multiple signaling pathways. Potential indirect activator of Zfp873 through its anti-inflammatory and epigenetic modulation, influencing the transcriptional regulation by RNA polymerase II. Curcumin's role may involve suppressing inflammatory pathways and modifying chromatin accessibility, enhancing Zfp873 activity in the nucleus. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor impacting gene transcription. Potential indirect activator of Zfp873 by inhibiting bromodomain proteins, altering chromatin structure, and influencing RNA polymerase II activity. JQ1's role involves modulating the epigenetic landscape to facilitate Zfp873 binding to cis-regulatory regions and enhance its transcriptional regulatory function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor influencing DNA methylation. Potential indirect activator of Zfp873 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. 5-Azacytidine's role involves epigenetic modifications that enhance Zfp873's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
HDAC inhibitor modulating gene expression. Potential indirect activator of Zfp873 by inhibiting HDACs, leading to increased histone acetylation and altered chromatin accessibility for RNA polymerase II. Sodium Butyrate's role involves epigenetic modifications that enhance Zfp873 binding to cis-regulatory regions, promoting its transcriptional regulatory activity in the nucleus. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
PARP inhibitor impacting chromatin structure. Potential indirect activator of Zfp873 through PARP inhibition, influencing RNA polymerase II-mediated transcription. A-485's role involves modulating the chromatin environment to facilitate Zfp873 binding to cis-regulatory regions and enhance its transcriptional regulatory function in the nucleus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenolic compound with diverse cellular effects. Potential indirect activator of Zfp873 through its antioxidant and epigenetic modulating properties. Resveratrol's role may involve influencing RNA polymerase II-mediated transcription by altering the chromatin landscape, promoting Zfp873 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor affecting chromatin remodeling. Potential indirect activator of Zfp873 by inhibiting HDACs, promoting histone acetylation, and influencing RNA polymerase II-specific DNA binding. SAHA's role involves epigenetic modifications that enhance Zfp873 binding to cis-regulatory regions, facilitating its transcriptional regulatory function in the nucleus. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Natural triterpenoid impacting multiple pathways. Potential indirect activator of Zfp873 through its anti-inflammatory and epigenetic modulating properties. Betulinic Acid's role involves influencing RNA polymerase II-mediated transcription by modifying chromatin accessibility, promoting Zfp873 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor influencing DNA methylation. Potential indirect activator of Zfp873 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. Decitabine's role involves epigenetic modifications that enhance Zfp873's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||