Rad9B Activators
Rad9B is a human homolog of the Schizosaccharomyces pombe Rad9 protein and a component of the Rad9-Rad1-Hus1 (9-1-1) complex, which is structurally similar to the PCNA (proliferating cell nuclear antigen) sliding clamp. Rad9B functions as a critical player in the DNA damage response (DDR) pathway, a crucial mechanism that maintains genomic stability by recognizing and repairing DNA lesions.Upon DNA damage, Rad9B is recruited to the site of damage and contributes to the activation of checkpoint signaling pathways. This activation halts cell cycle progression, allowing the cell time to repair the damage before proceeding with division. Rad9B's role is particularly important in the response to double-strand breaks (DSBs), one of the most lethal types of DNA damage.
The protein is also involved in the process of DNA repair, including both homologous recombination (HR) and non-homologous end joining (NHEJ), two major pathways that cells employ to fix DSBs. Through its interactions with other proteins in the DDR pathway, Rad9B helps to coordinate the complex series of events that lead to the repair of damaged DNA.Mutations or dysregulation of Rad9B and the 9-1-1 complex can lead to genomic instability, which is a hallmark of cancerous cells. Therefore, Rad9B is not only essential for normal cell cycle control and DNA repair but also for inhibiting the development of cancer by suppressing genomic instability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin induces DNA crosslinks, which can activate the DNA damage response and potentially upregulate Rad9B expression as part of the repair process. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes DNA strand breaks by inhibiting topoisomerase II, potentially increasing Rad9B expression to facilitate DNA repair mechanisms. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA and induces breaks, which could enhance Rad9B expression through the activation of DNA damage response pathways. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to DNA replication stress that may upregulate Rad9B as part of the checkpoint activation. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
MMS alkylates DNA, which can lead to the upregulation of Rad9B as the cell responds to this damage. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, causing DNA breaks that may trigger an increase in Rad9B expression for repair processes. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin causes oxidative DNA damage, which could lead to enhanced Rad9B expression as part of the cellular response. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms DNA crosslinks, potentially upregulating Rad9B expression during the DNA damage response. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide can induce oxidative stress and DNA damage, potentially increasing Rad9B expression as a protective response. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium is a genotoxic agent that can cause DNA damage, possibly leading to an upregulation of Rad9B in an attempt to maintain genomic integrity. | ||||||