Rad9B Inhibitors

RAD9B Inhibitors is a chemical class characterized by compounds designed to specifically target and impede the function of the protein RAD9B, primarily involved in the DNA damage response and cell cycle regulation. These inhibitors have garnered significant attention in the field of molecular biology and cancer research due to their to modulate key cellular processes related to DNA repair, replication, and checkpoint activation.

RAD9B, a member of the 9-1-1 complex, plays a vital role in maintaining genomic integrity. This complex, consisting of RAD9B, RAD1, and HUS1, serves as a sensor for DNA damage and replication stress. When DNA damage occurs, RAD9B recognizes the lesions or abnormalities and facilitates the activation of checkpoint kinases like CHK1. RAD9B inhibitors are designed to disrupt the interaction between RAD9B and other DNA repair or checkpoint proteins. They can function through various mechanisms, such as interfering with RAD9B's binding to DNA or blocking its kinase activity. By doing so, these inhibitors compromise the DNA damage response, impair the cell's ability to repair DNA lesions, and disrupt the regulation of cell cycle progression. As a result, cells exposed to RAD9B inhibitors may exhibit increased susceptibility to DNA damage and impaired checkpoint control.