PDLIM5 Activators
The class of chemicals categorized as PDLIM5 activators predominantly operate through the modulation of kinase activity and phosphorylation states of proteins, including PDLIM5 itself. Activators of this class facilitate the activation of protein kinase A (PKA) by increasing intracellular cAMP levels. PKA can then phosphorylate PDLIM5, thereby modulating its activity. These activators by boosting cAMP levels and subsequently promoting PKA activity, regulate the phosphorylation and consequent activity of PDLIM5.
PDLIM5 activators inhibit protein phosphatases, preserving the phosphorylation state of proteins. By inhibiting the dephosphorylation activity of these enzymes, these activators indirectly maintain the activation of PDLIM5. Similarly, a subset of PDLIM5 activators modulate PDLIM5 activity by altering the phosphorylation status of PDLIM5, but through the inhibition of PKA or PKC. Lastly, activators of this class activate PKC, leading to the phosphorylation of PDLIM5.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing intracellular cAMP levels. Raised cAMP can lead to activation of protein kinase A (PKA), which can phosphorylate PDLIM5, modulating its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX inhibits phosphodiesterases, thereby preventing the degradation of cAMP and potentially leading to increased PKA activity and subsequent PDLIM5 phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits protein phosphatases 1 and 2A, preventing the dephosphorylation of proteins. This can increase the phosphorylation state of PDLIM5, indirectly activating it. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, preserving the phosphorylation state of proteins. This can indirectly activate PDLIM5 by maintaining its phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate PDLIM5 and modulate its activity. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a potent activator of protein kinase C (PKC). Activated PKC can phosphorylate PDLIM5, modulating its activity. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a selective inhibitor of protein kinase C (PKC). By inhibiting PKC, it can modulate the phosphorylation status of PDLIM5 and indirectly activate it. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a potent and selective inhibitor of protein kinase C (PKC). By inhibiting PKC, it can modulate the phosphorylation status of PDLIM5 and indirectly activate it. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö 6983 is a potent inhibitor of protein kinase C (PKC). By inhibiting PKC, it can modulate the phosphorylation status of PDLIM5 and indirectly activate it. | ||||||