PDLIM5 Inhibitors
PDLIM5 inhibitors belong to a distinctive chemical class that plays a pivotal role in modulating cellular processes by targeting the PDZ and LIM domain-containing protein 5 (PDLIM5). PDLIM5 is a crucial scaffolding protein known for its involvement in diverse intracellular signaling pathways, particularly those related to cellular adhesion, migration, and cytoskeletal organization. This protein possesses both PDZ and LIM domains, which are crucial for mediating protein-protein interactions within the cell. The PDZ domain is involved in recognizing and binding to specific protein targets, while the LIM domain contributes to the regulation of cytoskeletal dynamics and gene expression.
PDLIM5 function by disrupting the interaction between PDLIM5 and its binding partners, thereby modulating downstream signaling cascades. These small molecules or compounds interfere with the formation of protein complexes that involve PDLIM5, influencing cellular processes associated with adhesion and migration. The specificity of PDLIM5 inhibitors lies in their ability to selectively target the PDZ and LIM domains of PDLIM5, making them promising tools for dissecting the intricate molecular pathways that rely on PDLIM5-mediated protein interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K, a kinase that is involved in the same signaling pathways as PDLIM5. It can therefore inhibit the function of PDLIM5 indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it could influence the signaling pathways that involve PDLIM5, thus indirectly inhibiting its function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective Rho-associated protein kinase inhibitor. It can indirectly inhibit PDLIM5 by inhibiting the activity of kinases that phosphorylate PDLIM5. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a potent, selective, and reversible JNK inhibitor. Inhibition of JNK could indirectly affect PDLIM5’s function in the JNK pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which can indirectly inhibit PDLIM5 as part of the MAPK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. It could indirectly inhibit the function of PDLIM5 in the p38 MAPK pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which indirectly affects PDLIM5’s function in the mTOR signaling pathway. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG-490 is an inhibitor of JAK2, which can indirectly inhibit PDLIM5, as it is involved in the JAK-STAT pathway. | ||||||
PP 1 | 172889-26-8 | sc-203212 sc-203212A | 1 mg 5 mg | $84.00 $142.00 | 6 | |
PP2 is an Src kinase inhibitor which can indirectly inhibit PDLIM5 by inhibiting the activity of kinases that phosphorylate PDLIM5. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can inhibit PDLIM5 indirectly by affecting tyrosine phosphorylation. | ||||||