MRE11_Mre11 Activators
MRE11_Mre11 activators form a specialized category of chemical compounds that interact with the MRE11 protein, also known as Mre11 in some organisms. MRE11 (Meiotic Recombination 11) is a highly conserved protein that plays a pivotal role in DNA double-strand break repair, recombination, and maintenance of genomic stability. It is a core component of the MRN (MRE11-RAD50-NBS1) complex, which is involved in sensing, processing, and coordinating responses to DNA damage. When activated by specific compounds, MRE11_Mre11 may undergo conformational changes or post-translational modifications that influence its role in DNA repair and recombination processes.
The activation of MRE11_Mre11 is a critical step in the DNA damage response and repair pathways, which are fundamental for preserving genomic integrity. These activators can modulate the functions of MRE11_Mre11, impacting the efficiency and accuracy of DNA repair mechanisms, as well as the cellular response to DNA damage. Understanding the chemical properties and mechanisms underlying MRE11_Mre11 activation is essential for unraveling the intricate processes involved in DNA repair and recombination, shedding light on how specific compounds can influence the cellular response to genetic insults. Research in this field can provide valuable insights into the broader landscape of genomic stability, DNA damage repair, and the mechanisms by which cells safeguard their genetic material.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is known to cause DNA damage, which potentially leads to the upregulation of MRE11 as part of the cellular response to repair DNA. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, induces DNA breaks, thereby possibly stimulating the expression of MRE11 to participate in DNA repair mechanisms. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts and crosslinks, potentially triggering an increase in MRE11 expression as a response to its role in DNA repair pathways. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
As an alkylating agent, Mitomycin C causes DNA crosslinking, which might lead to enhanced MRE11 expression as part of the DNA damage response. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin causes oxidative DNA damage, potentially inducing MRE11 expression to mediate the necessary repair processes. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
By inhibiting topoisomerase I, Camptothecin introduces DNA breaks, potentially upregulating MRE11 for DNA repair. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil, a pyrimidine analog, can lead to DNA damage, possibly stimulating MRE11 expression as a cellular response to maintain DNA integrity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate, a dihydrofolate reductase inhibitor, may indirectly cause DNA damage, potentially upregulating MRE11 expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
As a ribonucleotide reductase inhibitor, Hydroxyurea can lead to DNA replication stress, potentially enhancing MRE11 expression in response. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen, while primarily known for its estrogen receptor modulation, may indirectly affect DNA repair mechanisms, potentially influencing MRE11 expression. | ||||||