MAP17 Activators
The class of MAP17 Activators encompasses a diverse group of chemical compounds that, through their individual mechanisms, can enhance the functional activity of MAP17. Forskolin, by raising intracellular cAMP levels, activates PKA which is known for its role in phosphorylating various proteins, leading to an enhanced activity of MAP17. Similarly, EGF works through the EGFR, setting off a cascade of phosphorylation events within the MAPK/ERK pathway that can subsequently upregulate MAP17 activity. PMA, through PKC activation, and Ionomycin, by increasing intracellular calcium levels, both contribute to the activation of kinases capable of enhancing MAP17 activity.
Further, Insulin, through the PI3K/Akt pathway, and Nicotinamide mononucleotide, by increasing NAD+ levels and influencing SIRT1 activity, both can impact MAP17 activity through phosphorylation and deacetylation processes, respectively. Resveratrol similarly impacts SIRT1, leading to enhanced MAP17 function via deacetylation mechanisms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can then phosphorylate target proteins, potentially enhancing the activity of MAP17 by increasing its phosphorylation status. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a known activator of protein kinase C (PKC), which can phosphorylate a wide range of target proteins. PKC activation can lead to the enhancement of MAP17 function through direct phosphorylation or by modulating the cellular environment to favor MAP17 activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. Increased intracellular calcium can enhance MAP17 function by activating calcium/calmodulin-dependent protein kinases (CaMKs). | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin initiates signaling through the insulin receptor, activating PI3K/Akt pathway. Akt can phosphorylate multiple downstream targets, potentially enhancing MAP17 activity by improving its stabilization or interaction with other proteins. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor of NAD+, which is required for SIRT1 activity. SIRT1 deacetylation of target proteins can enhance MAP17 function by post-translational modifications that improve its stability or activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate SIRT1, which can deacetylate proteins and affect their activity. By enhancing SIRT1 activity, resveratrol can indirectly increase MAP17 activity through deacetylation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which could lead to changes in the cellular environment that enhance MAP17 activity. For example, reduced NF-κB activity can alter the expression of proteins that interact with or regulate MAP17. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, a kinase that phosphorylates and can lead to the degradation of proteins. Inhibition of GSK-3 could enhance MAP17 activity by stabilizing it or altering its interaction with other proteins. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor, leading to increased acetylation of histones and a more open chromatin structure. This change can enhance MAP17 activity by affecting the cellular environment in a way that promotes its function. | ||||||