JAGN1 Activators
AGN1 Activators are a class of chemical compounds that enhance the functional activity of JAGN1, a protein known for its role in endoplasmic reticulum (ER) function, calcium signaling, and lysosomal and mitochondrial function. Some JAGN1 activators, such as Rapamycin, Bafilomycin A1, and Chloroquine, act by influencing autophagy and lysosomal function, processes in which JAGN1 plays a part. Rapamycin, an mTOR inhibitor, enhances JAGN1 activity by triggering autophagy. Bafilomycin A1, a V-ATPase inhibitor, and Chloroquine, a lysosomotropic agent, alter lysosomal function, leading to enhanced JAGN1 activity.
Other JAGN1 activators, including Verapamil, Cyclopiazonic Acid, and Thapsigargin, function by impacting calcium signaling, a process in which JAGN1 is involved. For instance, Verapamil, a calcium channel blocker, enhances JAGN1 activity by increasing intracellular calcium levels. Similarly, Cyclopiazonic Acid and Thapsigargin, both inhibitors of the SERCA pump, also lead to increased cytosolic calcium and enhanced JAGN1 activity. Furthermore, some JAGN1 activators, such as Nigericin, Monensin, FCCP, Valinomycin, Rotenone, and Antimycin A, impact JAGN1 activity by influencing lysosomal and mitochondrial function. Nigericin and Monensin, both ionophores, alter lysosomal ion balance and enhance JAGN1 activity. FCCP, a protonophore, and Valinomycin, a potassium ionophore, disrupt mitochondrial ion gradients and enhance JAGN1 function. Lastly, Rotenone and Antimycin A, both inhibitors of the mitochondrial electron transport chain, can also enhance JAGN1 activity by inhibiting the electron transport chain.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, and JAGN1 is known to be involved in mTOR signaling. Inhibition of mTOR can enhance the functional activity of JAGN1 by triggering autophagy, a process in which JAGN1 plays a part. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a V-ATPase inhibitor. JAGN1 is involved in lysosomal function, and by inhibiting V-ATPase, Bafilomycin A1 can lead to the accumulation of lysosomal substrates, enhancing the functional activity of JAGN1. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a lysosomotropic agent, and JAGN1 is implicated in lysosomal function. Chloroquine can alter lysosomal pH, which can enhance the functional activity of JAGN1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker. JAGN1 is involved in calcium signaling, and by blocking calcium channels, Verapamil can lead to increased intracellular calcium, enhancing the functional activity of JAGN1. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA). By inhibiting SERCA, it can increase cytosolic calcium levels, which can enhance the functional activity of JAGN1, known to be involved in calcium signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an inhibitor of the SERCA pump, and JAGN1 is involved in calcium signaling. By inhibiting the SERCA pump, Thapsigargin can increase cytosolic calcium levels, enhancing the functional activity of JAGN1. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $46.00 $112.00 $240.00 $7079.00 $27417.00 | 9 | |
Nigericin is a potassium ionophore that can affect lysosomal function. JAGN1 is known to be involved in lysosomal function, and by altering lysosomal ion balance, Nigericin can enhance the functional activity of JAGN1. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore that can affect lysosomal function. As JAGN1 is known to be involved in lysosomal function, by altering lysosomal ion balance, Monensin can enhance the functional activity of JAGN1. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP is a protonophore and uncoupler of oxidative phosphorylation in mitochondria. JAGN1 is known to be involved in mitochondrial function, and by disrupting proton gradients, FCCP can enhance the functional activity of JAGN1. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin is a potassium ionophore that can affect mitochondrial function. Since JAGN1 is known to be involved in mitochondrial function, by altering mitochondrial ion balance, Valinomycin can enhance the functional activity of JAGN1. | ||||||