JAGN1 Antibody (C-3): sc-515306

JAGN1 Antibody (C-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects JAGN1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JAGN1 Antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. JAGN1 consists of 183 amino acids and plays a crucial role in regulating the unfolded protein response, which maintains cellular homeostasis and prevents stress-induced apoptosis. Dysregulation of JAGN1 can lead to various diseases, including neurodegenerative disorders and cancer, highlighting JAGN1′s importance in cellular health. JAGN1 is located on human chromosome 3, a region significant for involvement in numerous genetic diseases and harboring key tumor suppressor genes. Understanding JAGN1′s function and implications in disease processes can provide valuable insights for therapeutic interventions and biomarker development.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

JAGN1 Antibody (C-3) References:

1. Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.  |  Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
2. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
3. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
4. Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2.  |  Yue, Y., et al. 2005. Cytogenet Genome Res. 108: 98-105. PMID: 15545721
5. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
6. Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'.  |  Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
7. The DNA sequence, annotation and analysis of human chromosome 3.  |  Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
8. Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3.  |  Nareyeck, G., et al. 2006. Exp Eye Res. 83: 858-64. PMID: 16750193

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-JAGN1 Antibody (C-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-JAGN1 Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

JAGN1 Antibody (C-3) Specifications

Alternate Product Name: JAGN1

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 60-85

Epitope Target: JAGN1

Epitope Species: human

Product Reactivity/Detection: JAGN1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for JAGN1 Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin