Elmo3 Activators
Elmo3, short for Engulfment and Cell Motility 3, is part of the ELMO family of proteins and is implicated in the intricate processes of cytoskeletal reorganization and cellular locomotion. Though less characterized than its relatives Elmo1 and Elmo2, Elmo3 is believed to contribute similarly to cellular guidance systems by acting as a guanine nucleotide exchange factor (GEF) for small GTPases like Rac1. These GTPases are pivotal for actin cytoskeleton dynamics, which underpin a range of cellular activities including phagocytosis, migration, and adhesion The ELMO proteins typically collaborate with Dock180-family members to facilitate the exchange of GDP for GTP on Rac, triggering its active state. Upon activation, Rac promotes the assembly of actin filaments, leading to the formation of structures such as lamellipodia and filopodia, essential for cellular movement and the engulfment of particles or cells.
Elmo3's role, while not as extensively studied, is thought to be nuanced and possibly distinct in certain cellular contexts or tissues. Its expression patterns and functional engagements may be governed by developmental cues and environmental stimuli, implicating it in processes beyond just cell motility, potentially including immune cell function and developmental signaling pathways.Continued research is needed to fully elucidate Elmo3's specific mechanisms of action and regulatory networks. Understanding Elmo3 is particularly relevant as aberrations in cytoskeletal dynamics and cell motility are linked to various pathologies, including metastatic cancer and immune disorders, making ELMO proteins attractive subjects for intervention research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A kinase inhibitor that could affect multiple signaling pathways, potentially altering Elmo3 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that might modify cell survival and motility pathways, influencing Elmo3 expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Induces ER stress and could modulate cell signaling pathways, affecting Elmo3 expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits protein synthesis, potentially leading to cellular stress responses that upregulate Elmo3 expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can influence NF-κB signaling, possibly impacting Elmo3 expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor, potentially affecting cellular stress responses and Elmo3 expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which might alter stress response pathways and Elmo3 expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibits NF-κB activation, which could modify immune responses and potentially affect Elmo3 expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Induces metabolic stress by inhibiting glycolysis, which could lead to changes in Elmo3 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, which might influence Elmo3 expression by altering cell growth and survival pathways. | ||||||