DNA pol λ Activators
DNA pol λ activators represent a unique class of chemicals that are involved in modulating the cellular response to genomic maintenance. These activators are diverse in structure and origin, but they share the common capability of enhancing the expression of DNA polymerase lambda (DNA pol λ), a key enzyme in the DNA repair machinery of cells. Their modes of action are varied, reflecting the complexity of cellular regulation and the multitude of pathways that converge on the maintenance of DNA integrity. Some of these compounds interact directly with the cellular DNA, causing damage that necessitates repair, while others influence the expression of DNA pol λ through epigenetic modifications or by affecting the stability and interaction of proteins involved in gene regulation.
The range of DNA pol λ activators includes agents that cause oxidative stress within the cell, such as hydrogen peroxide and paraquat, which can lead to increased expression of DNA repair enzymes as part of the cellular response to oxidative DNA damage. Other chemicals, like cisplatin and etoposide, introduce cross-links or breaks in the DNA structure, directly triggering the DNA damage response pathways that can result in the upregulation of DNA pol λ. Meanwhile, epigenetic modulators like histone deacetylase inhibitors (e.g., SAHA and Trichostatin A) alter the chromatin state, potentially increasing the expression of DNA repair genes. Compounds like rapamycin affect signaling pathways, such as those regulated by mTOR, which can also lead to an increase in DNA repair protein levels as part of the cellular stress response. These activators do not function in isolation but are part of a network of signals that collectively ensure the cell is equipped to handle genomic stress, highlighting the intricate relationship between cellular signaling, gene expression, and DNA repair processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Generates oxidative DNA damage, which can enhance the transcription of DNA repair genes, including possibly DNA pol λ, as the cell responds to repair the oxidative lesions. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Leads to oxidative stress and subsequent DNA damage, which may trigger a cellular response that includes upregulation of DNA repair proteins like DNA pol λ. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Alters chromatin structure to facilitate access of transcription machinery and potentially upregulates genes involved in DNA repair, including DNA pol λ. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Affects chromatin remodeling and gene expression, which may include the upregulation of DNA repair genes such as DNA pol λ in response to increased accessibility. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Reactivates silenced genes including those for DNA repair by DNA demethylation, potentially increasing the expression of DNA pol λ. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Induces heat shock response, which may stabilize proteins involved in DNA repair regulation, possibly leading to increased DNA pol λ levels. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Activates p53 by preventing its degradation, which may lead to the transcriptional activation of DNA repair genes including DNA pol λ. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
As an antioxidant, may activate signaling pathways that lead to the upregulation of genes involved in the oxidative stress response, potentially including DNA pol λ. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
May modulate transcription factors and affect gene expression profiles, possibly enhancing the expression of DNA repair enzymes like DNA pol λ. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, which can activate stress response pathways and may lead to an increase in DNA repair proteins, potentially including DNA pol λ, to maintain genomic stability. | ||||||