CRELD1 Inhibitors
CRELD1 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the CRELD1 protein, also known as Cysteine-rich with EGF-like domains protein 1. CRELD1 is a membrane-associated protein found in various tissues, with prominent expression in the developing heart and neural tissues. It is characterized by the presence of EGF-like domains and is believed to play crucial roles in cellular adhesion, tissue development, and cell signaling. Inhibitors designed to target CRELD1 are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this protein.
The development of CRELD1 inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with CRELD1 and modulate its activity. By inhibiting CRELD1, these compounds can potentially disrupt its functions in cell adhesion and signaling pathways, depending on the specific context. Researchers use CRELD1 inhibitors to explore the intricate roles played by CRELD1 in cellular processes, uncovering its contributions to phenomena such as tissue morphogenesis, neural development, and cell-cell interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a hypomethylating agent that can demethylate DNA and potentially suppress gene expression. Its action on DNA methylation could theoretically affect the transcription of CRELD1. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor that can cause changes in chromatin structure, potentially leading to altered expression of genes including CRELD1 by affecting histone acetylation levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to intercalate into DNA, which can disrupt DNA replication and transcription. This action might non-specifically inhibit the expression of certain genes such as CRELD1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that has been shown to modulate gene expression through epigenetic mechanisms. It could influence the expression of CRELD1 indirectly via these pathways. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate metal ions and modulate the activity of various metalloenzymes, which might indirectly lead to changes in gene expression, including that of CRELD1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid affects gene transcription through its action on retinoic acid receptors and could conceivably down-regulate CRELD1 expression through changes in transcriptional regulation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor that can influence the turnover of transcription factors and other regulatory proteins, potentially affecting the expression of CRELD1. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide has been reported to inhibit translation initiation, which could theoretically lead to a reduction in CRELD1 protein levels by preventing its synthesis. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a cyclin-dependent kinase inhibitor, which could lead to cell cycle arrest and alterations in the expression of genes, such as CRELD1, that are regulated during the cell cycle. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in the control of protein synthesis and cell proliferation. Inhibition of this pathway could potentially down-regulate CRELD1 expression. | ||||||