CPP32 p11 Activators
CPP32 Activators consist of a diverse array of chemical compounds that can enhance the proteolytic activity of CPP32, an essential executor caspase in the apoptosis pathway. Z-DEVD-FMK, by competitively inhibiting other caspases, can increase the substrate availability for CPP32, thereby augmenting its activity. Similarly, Etoposide and Camptothecin, both DNA-damaging agents, induce apoptosis which entails the activation of CPP32 to dismantle cellular components. Compounds such as Tunicamycin, Thapsigargin, and Brefeldin A stress the endoplasmic reticulum, triggering an apoptotic response that culminates in CPP32 activation. Betulinic Acid and Sulforaphane, through mitochondrial pathway induction, and Arsenic Trioxide, via oxidative stress, also contribute to apoptosis, necessitating the action of CPP32 to execute cell death.
Moreover, Staurosporine, a kinase inhibitor, can initiate apoptosis by a broad mechanism that includes the activation of CPP32. Cycloheximide enhances CPP32 activity by inducing apoptosis due to inhibition of protein synthesis. The incorporation of TRAIL, although a biological ligand, in its synthetic form, directly interacts with death receptors, setting off a cascade that activates CPP32.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caspase-3 Inhibitor | 210344-95-9 | sc-3075 | 0.5 mg | $112.00 | 57 | |
This is a synthetic peptide that functions as an irreversible inhibitor of caspases. By binding to caspases other than CPP32, it can enhance the activity of CPP32 by reducing competition for substrates, thereby indirectly increasing CPP32's proteolytic activity against its specific substrates. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent non-selective inhibitor of protein kinases. It can induce apoptosis through a pathway that includes the activation of CPP32, leading to the proteolytic cleavage of cellular proteins and the execution phase of cell apoptosis. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that can induce DNA damage and apoptosis. It facilitates the release of cytochrome c from mitochondria, which indirectly activates CPP32 as part of the apoptotic cascade. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, leading to ER stress and the unfolded protein response, which can trigger apoptosis and consequently activate CPP32. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), causing calcium release and inducing ER stress, which can lead to the activation of CPP32 as part of the apoptosis pathway. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts ER-Golgi transport, leading to ER stress and activation of apoptosis signaling pathways that include the activation of CPP32. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid induces apoptosis in cancer cells through mitochondrial pathway activation, which includes the activation of CPP32. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can induce apoptosis in certain cancer cell lines, leading to the activation of CPP32 as a component of the apoptotic process. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that induces DNA damage and apoptosis, leading to the activation of CPP32 in the apoptotic signaling pathways. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide is known to induce apoptosis via reactive oxygen species production and mitochondrial dysfunction, which can lead to the activation of CPP32. | ||||||