Molecular structure of Caspase-3 Inhibitor, CAS Number: 210344-95-9
Caspase-3 Inhibitor (CAS 210344-95-9)
See product citations (57)
Alternate Names:
Z-DEVD-FMK
Application:
Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number:
210344-95-9
Purity:
≥90% (solid)
Molecular Weight:
668.66
Molecular Formula:
C30H41FN4O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Caspase-3 inhibitor (Z-DEVD-FMK) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).
Caspase-3 Inhibitor (CAS 210344-95-9) References
- Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. | Henshall, DC., et al. 2000. J Neurochem. 74: 1215-23. PMID: 10693954
- Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. | Kugawa, F., et al. 2000. Biol Pharm Bull. 23: 930-5. PMID: 10963298
- Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways. | Nagarajah, NS., et al. 2004. Mol Cancer. 3: 38. PMID: 15613236
- The role of caspase-3 activation in phencyclidine-induced neuronal death in postnatal rats. | Wang, CZ. and Johnson, KM. 2007. Neuropsychopharmacology. 32: 1178-94. PMID: 16985504
- Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO. | Yoshimori, A., et al. 2007. BMC Pharmacol. 7: 8. PMID: 17594508
- Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. | Cervantes, J., et al. 2008. Cell Microbiol. 10: 41-52. PMID: 17662073
- Caspase-3-dependent mitotic checkpoint inactivation by the small-molecule inducers of mitotic slippage SU6656 and geraldol. | Riffell, JL., et al. 2011. Mol Cancer Ther. 10: 839-49. PMID: 21441410
- Induction of caspase-3-dependent apoptosis in human leukemia HL-60 cells by δ-elemene. | Ying, J., et al. 2011. Yakugaku Zasshi. 131: 1383-94. PMID: 21881314
- CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. | Schlegel, J., et al. 1996. J Biol Chem. 271: 1841-4. PMID: 8567626
- Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells. | Masuda, Y., et al. 1997. Biochem Biophys Res Commun. 234: 641-5. PMID: 9175767
- ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. | Nicholson, DW. 1996. Nat Biotechnol. 14: 297-301. PMID: 9630889
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
- Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. | Brockstedt, E., et al. 1998. J Biol Chem. 273: 28057-64. PMID: 9774422
Inhibitor of:
Apoptosis, C9orf82, caspase-10, caspase-13, caspase-3, caspase-6, caspase-7, caspase-8, Chemical and Peptide Caspase, CPP32 p11, ICE p20, ICH-1S, Pdcd-7, Programmed cell death (PDCD), RBP-Jκ, and reaper.Activator of:
APC10, CPP32 p11, and IRF-2BP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-3 Inhibitor, 0.5 mg | sc-3075 | 0.5 mg | $112.00 |