TRIM35 Activators
TRIM35 Activators represent a distinctive class of compounds that exert their biological effects by modulating the activity of TRIM35, a member of the tripartite motif (TRIM) protein family. TRIM35 is an E3 ubiquitin ligase, a class of enzymes involved in the ubiquitin-proteasome system responsible for targeted protein degradation. The activation of TRIM35 involves a complex interplay of cellular signaling pathways and molecular interactions. The small molecules classified as TRIM35 Activators function by specifically enhancing the enzymatic activity or stabilizing the active conformation of TRIM35, ultimately leading to an increased ubiquitination of its substrate proteins.
The molecular mechanisms underlying the activation of TRIM35 by these compounds are intricate and involve the recognition of specific binding sites on the TRIM35 protein. Through this targeted interaction, TRIM35 Activators fine-tune the ubiquitin ligase activity of TRIM35, impacting downstream cellular processes that rely on the regulated degradation of target proteins. The development of TRIM35 Activators represents a novel avenue for modulating intracellular processes associated with the ubiquitin-proteasome system, providing researchers with valuable tools to dissect the intricate regulatory networks governing protein turnover. Further investigations into the structural basis of TRIM35 activation and the identification of downstream cellular pathways influenced by these compounds hold promise for advancing our understanding of cellular homeostasis and may uncover new opportunities for research interventions in various diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea that has been shown to modulate the ubiquitin-proteasome system. EGCG can enhance the degradation of misfolded proteins, a process that TRIM35 is known to be involved in by promoting ubiquitination. This suggests that EGCG could enhance TRIM35's functional activity in protein quality control. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound in cruciferous vegetables that influences the NF-κB signaling pathway. TRIM35 has been reported to regulate immune responses, potentially through modulation of this pathway. Sulforaphane's action on NF-κB could lead to conditions that favor TRIM35-mediated regulation of immune response genes, thereby enhancing the functional activity of TRIM35. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, from turmeric, is known to interact with various molecular targets involved in inflammation. It can inhibit the activation of the transcription factor NF-κB, which could enhance the regulatory role of TRIM35 in immune and inflammatory responses by modulating the signaling environment to favor TRIM35 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound that can activate SIRT1, an NAD+-dependent deacetylase. Since SIRT1 can modulate the activity of various proteins through deacetylation, its activation by resveratrol could potentially enhance the activity of TRIM35 indirectly by creating a more favorable deacetylation landscape for TRIM35 to function in cellular stress responses. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine selectively increases the levels of reactive oxygen species (ROS) within cells. The increase in ROS can affect multiple signaling pathways, including those involved in cellular stress response, potentially creating conditions that enhance the function of TRIM35 in the response to oxidative stress, given its role in ubiquitination and proteasome-mediated degradation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A, found in Withania somnifera, can disrupt proteasomal activity. By modifying proteasomal function, Withaferin A could indirectly increase the demand for TRIM35's ubiquitination activity, as TRIM35 is implicated in tagging proteins for degradation, which may enhance its functional activity in the cell. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a sesquiterpene lactone that can inhibit the NF-κB pathway. By inhibiting this pathway, Parthenolide could increase the reliance on TRIM35's role in immune regulation, thus potentially enhancing the functional activity of TRIM35 in immune response pathways. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone, the active constituent of Nigella sativa seeds, exhibits antioxidant properties and can modulate the JAK/STAT pathway. Since TRIM35 is involved in immune response regulation, the modulation of JAK/STAT signaling by Thymoquinone could lead to an environment that enhances TRIM35's regulatory functions. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic acid is a natural pentacyclic triterpenoid that can modulate pathways involved in cellular differentiation and apoptosis. Its action on these pathways could enhance the role of TRIM35 in the regulation of cell proliferation and apoptosis, indirectly enhancing TRIM35's activity. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid is a triterpenoid that can influence pathways related to liver health and regeneration. Given that TRIM35 is implicated in the regulation of cell growth, oleanolic acid could enhance TRIM35's activity by influencing cellular pathways associated with growth and regeneration. | ||||||