ZRANB3 Inhibitors
ZRANB3 inhibitors belong to a specialized class of chemical compounds designed to target the ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3) protein. ZRANB3 is a multifunctional protein that plays diverse roles in cellular processes, including DNA replication, DNA repair, and the maintenance of genomic stability. It contains several functional domains, including zinc fingers and a RAN-binding domain, which enable it to interact with various macromolecules and participate in different cellular pathways. One of its most notable functions is its involvement in the regulation of DNA replication fork stability and the restart of stalled replication forks.
Inhibitors of ZRANB3 are designed to interact with this protein and disrupt its various functions. These inhibitors may operate through various mechanisms, such as binding to specific domains of ZRANB3 or altering its interactions with other cellular components. By inhibiting ZRANB3, these compounds can interfere with processes related to DNA replication and repair, which are critical for maintaining genome integrity and preventing the accumulation of genetic mutations. Research on ZRANB3 inhibitors is primarily focused on elucidating the molecular mechanisms by which ZRANB3 contributes to DNA replication and repair, shedding light on the intricate processes that safeguard the stability of the genetic material and how they may be targeted for various research purposes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
A PARP inhibitor that impacts DNA repair mechanisms and may indirectly influence the expression of repair proteins like ZRANB3. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $178.00 $270.00 $712.00 | 3 | |
Another PARP inhibitor that can affect the cellular response to DNA damage, potentially altering ZRANB3 expression. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Also a PARP inhibitor, it may impact the signaling pathways associated with DNA repair, potentially affecting ZRANB3 expression. | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
A potent PARP inhibitor that may indirectly influence the expression of DNA damage response proteins such as ZRANB3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor that can disrupt cell signaling pathways and potentially impact ZRANB3 expression as part of the stress response. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor, which impacts AKT signaling and could affect the expression of proteins involved in DNA repair. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
An inhibitor of DNA topoisomerase I, which can cause DNA damage and potentially affect expression of relevant repair proteins. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Targets the ATR kinase involved in DNA damage response, possibly influencing the expression of associated proteins like ZRANB3. | ||||||
Ceralasertib | 1352226-88-0 | sc-507439 | 10 mg | $573.00 | ||
An inhibitor of the ATR kinase, and by modulating DNA damage response, it could affect ZRANB3 expression. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
A DNA-PK inhibitor, which could alter the cellular response to DNA damage and influence the expression of repair proteins. | ||||||