ZRANB3 Activators
ZRANB3 is a protein that plays a crucial role in DNA damage response and repair mechanisms, particularly in the context of the replication stress response. ZRANB3 activators are a class of chemical compounds that enhance the protein's activity by modulating the biochemical pathways in which it operates. The activation of ZRANB3 is primarily through the induction of post-translational modifications that increase its affinity for DNA or its catalytic activity. For instance, certain small molecule activators might facilitate the phosphorylation of ZRANB3 through the activation of upstream kinases that recognize ZRANB3 as a substrate. This post-translational modification can amplify ZRANB3's ability to bind to DNA, thereby accelerating its role in processing DNA structures that arise during replication stress. Another group of activators might work by stabilizing ZRANB3 or preventing its ubiquitination and subsequent degradation, thereby enhancing the steady-state levels of ZRANB3 and ensuring its availability for engaging with the replication machinery.
Additionally, some ZRANB3 activators could indirectly enhance its activity by modulating the cellular milieu that favors the recruitment of ZRANB3 to sites of DNA damage. Chemicals that mimic the cellular signals of replication stress or DNA damage can increase the localization of ZRANB3 to the nucleus, where it exerts its activity. These compounds may include mimetics of DNA damage signals or small molecules that induce a cellular stress response, leading to the activation of the ATR-CHK1 pathway, which is known to be involved in the recruitment of DNA repair proteins. By co-opting these pathways, ZRANB3 activators ensure that the protein is not only present in higher functional concentrations but is also correctly positioned in the cell to interact with its target DNA sequences, thus bolstering the DNA repair process. Through these mechanisms, ZRANB3 activators play a pivotal role in maintaining genomic stability by enhancing the intrinsic activity of ZRANB3 and promoting its role in the replication stress response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that induces DNA double-strand breaks. ZRANB3 is known to be involved in the homologous recombination repair pathway, and the presence of DNA damage from etoposide could enhance ZRANB3 activity by increasing its recruitment to DNA damage sites. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is an inhibitor of NEDD8-activating enzyme, affecting protein neddylation. This can lead to the stabilization of proteins involved in DNA damage response, potentially enhancing the role of ZRANB3 in DNA repair pathways by increasing the persistence of structures where ZRANB3 operates. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $138.00 | 4 | |
Mirin is an inhibitor of the MRE11-RAD50-NBS1 (MRN) complex, which is involved in the detection of DNA double-strand breaks. Inhibition of MRN could potentiate the recruitment of ZRANB3 to sites of DNA damage, thereby enhancing its repair function. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a cyclin-dependent kinase (CDK) inhibitor that can disrupt cell cycle progression. Given that ZRANB3’s activity is linked to certain phases of the cell cycle, particularly in response to replication stress, Roscovitine may enhance ZRANB3 function by causing cell cycle arrest and increasing its accessibility to replication forks. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea is a ribonucleotide reductase inhibitor that induces replication stress by depleting dNTP pools. Induced replication stress can enhance ZRANB3 activity, as ZRANB3 responds to such stress by promoting replication fork restart and repair. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is known to inhibit ATR and ATM kinases, and by doing so, it can potentiate the activity of DNA repair proteins such as ZRANB3 by increasing the need for their DNA repair and replication stress response functions. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a DNA polymerase inhibitor that induces replication fork stalling. Stalled replication forks may enhance the recruitment and activity of ZRANB3, which is involved in replication stress response and the resolution of these forks. | ||||||